Protein Alignment skd and med13a

DIOPT Version :9

• Sequence 1: NP_730591.2
• Gene: skd / 43906
• FlyBaseID: FBgn0003415
• Length: 2768
• Species: Drosophila melanogaster
• Sequence 2: NP_001268397.1
• Gene: med13a / 100004024
• ZFINID: ZDB-GENE-070627-13
• Length: 2157
• Species: Danio rerio
• Alignment Length: 2907
• Identity: 777/2907 - (26%)
• Similarity: 1187/2907 - (40%)
• Gaps: 918/2907 - (31%)

  Fly     9 NGASLEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPL------ADPILRSYSRCIQADMLCVW 67
            |||||||||:|.:.|.||.||||:::| .:.|  .|.|:      .||||.|:|||:::|:|.||
Zfish     8 NGASLEDCHSNLFYLADLTGIKWKRYV-WQGP--ISAPMLFPVTEEDPILCSFSRCLKSDVLSVW 69

  Fly    68 RRVQSTKTDHADPNALTFEMTTSTKVHPPLSLAAAKELWIFWYGEEPDLSELVDAELLRVAANQA 132
            ||.|.                           ...:|||:||:|::|:.::|:..||      .|
Zfish    70 RRSQR---------------------------QGRRELWLFWWGDDPNFADLIHHEL------TA 101

  Fly   133 LWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFT 197
            ..:|.|:..|:||||:|||||:|||:||.::.:..||.|||||:|....::...: .:|||.|||
Zfish   102 EDDGVWESGLSYECRTLLFKAIHNLLERCLMNRSFVRIGKWFVKPYEKDEKPINK-REHLSCSFT 165

  Fly   198 FFVHGDT-VCASIDLREHPAVRPLTKEHLTEAAAAFAAASSPPGSNGSAASAGGAVPNPGQDPNG 261
            ||:|||: ||.|:::.:|..|..|:::|||.|    ..||||
Zfish   166 FFLHGDSNVCTSVEINQHQPVYHLSEDHLTLA----QQASSP----------------------- 203

  Fly   262 ASMDGLDGGEGAAKAAPPPHARKVMLAPFGIAGILTGNSYKASDPIAEKILEDWASFFPL--CNK 324
                                 .:|:|:|||:.|.|||.|:|.|||..:|::|:|..|:|:  .:|
Zfish   204 ---------------------FQVILSPFGLNGTLTGQSFKLSDPPTQKLIEEWNQFYPISPTSK 247

  Fly   325 DNT-----------DVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEFVEMQKMQSSV-----A 373
            ::.           |....|||:.||.:|.:|...|||.                ||.:     .
Zfish   248 ESAEDKMEDIDWEDDSLAAVEVLVGGVRMVYPACLVLVP----------------QSDIPTITQT 296

  Fly   374 GAAAESAVLASLSCPPGAASAPSSMGAAPSATAVPLGPASLNAPALAGAGVGATASSAAKEISRK 438
            |::..:||.::      ....|:| ...|:.::|.|.|              .|:...|:.:...
Zfish   297 GSSHCTAVYSN------GHQVPAS-NRDPAISSVTLTP--------------PTSPEEAQTVHSH 340

  Fly   439 AA------PQAVSALERLAFQPYYDQRPTSGFTFNTNNTH---IPASAAVEMPERTWQDCVMNTL 494
            :|      |.|:                 .||:.:..:.|   ||...|.::.|..||:|.:|
Zfish   341 SAQKWMRLPVAM-----------------DGFSVDNTSHHGGKIPRRMASQVVETVWQECNIN-- 386

  Fly   495 HVDAAAAAAAVASSTPASGTGSLSADGDENEQNKPPQDSKQLVQQQIQQQQQRQKLWNFVDPMQK 559
                .|......|:|.::||                .:.:.|:         :...|:|||..|:
Zfish   387 ----RAQNKRKFSATASNGT----------------SEEETLI---------KVGAWDFVDSTQR 422

  Fly   560 APCICTNAQCNSSSSISNISNNKRPQQPLGSPALRAAVTGGSGNKSSSSSSSSSSSSSSSSSYQQ 624
            :.|     .|:...::...:::...|.|......:..:...:|.|....
Zfish   423 SNC-----NCSRHKTLKQRASSTPGQPPTAGQTQQPPIKHKAGEKPEKG---------------- 466

  Fly   625 QHYHQQHLQQQQQQRPGTPVLPATAATSSHHSSSLSNTSASNSSAATPRRHNVPFHKRLLHSLAS 689
                     .:||:||.||.         ||.:|:.......:.|:..:|             .:
Zfish   467 ---------DKQQKRPQTPF---------HHRNSVCEDVTMETDASAGQR-------------LA 500

  Fly   690 TASSTASTFRAKNHSNTTTDTNIPKQRHLGNTPHGTPHGGASTYSRNSLGGDSSMPVASVESPAT 754
            .....:..|.....::..|.:..|:.           |.||.    :::|  ||.|...|.||..
Zfish   501 LRGQESGRFPGLRPTDVGTGSKPPQL-----------HSGAG----STVG--SSGPTEMVGSPQP 548

  Fly   755 PAPSPHPNSAHSQPTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNT-PAPTPTDQHDSK 818
            |..||||.....:|:                   ..::.|.|| .|....:| |...|....|..
Zfish   549 PPLSPHPCERGEEPS-------------------DTIKNPSTP-QHFYPPSTEPCLLPQKGPDDA 593

  Fly   819 SI--TASPYVHQTPSVEPPSYTDHAAGGGPAGGQGLGTGPGSVPAQQPATP--TAATSAGGAGSG 879
            .:  ...|:        ||:|                      |.....||  :||.:....||.
Zfish   594 RLEPLTQPF--------PPAY----------------------PETLEPTPYISAAVNMDDDGSH 628

  Fly   880 GPSNAIGANAVGTISVKKLEMQQQTPSAAMAIKQEPGAQGR-----GVGGVTSTTEALNNFKRLY 939
            .|......       .::.:.:..||:.       ||.:.|     |..|:.|.||::...|||
Zfish   629 APWRFFNL-------PRRKDAEFPTPTL-------PGDKLREEASLGAEGIMSVTESMAASKRL- 678

  Fly   940 NPPKLTLKDPDSFYDEEWLKEVIYDFQYQEYWDYSTVKRPKMEKQRRPRY-AKNLYEGQNHVKPV 1003
                  ||..|                          :|.:|..||:.:: |..:.:|.:  :|.
Zfish   679 ------LKVSD--------------------------ERIQMYLQRQNQHLAAAITDGDH--EPE 709

  Fly  1004 MPSPGSVYGSQLLSLDESASQAGGRGGGGQAAGSSGGGLVGIANSTASGSDVEADGSSFFQGLNI 1068
            :.....|.|....:..:...:||                                         :
Zfish   710 VDPYAFVDGDVKFTFSDKKDKAG-----------------------------------------L 733

  Fly  1069 KTEPGLHSPSCKETSKSSGGNSSGGGS--------GSGGNLFTAEGLNPSLNDLEQLFETSSNDE 1125
            :.|||       :..|...||::...:        .:..:|.....|..|:.||:.||.:..:::
Zfish   734 EREPG-------KKHKGEDGNAASDDAQRAAAHNRAASTSLIHDSDLAVSIKDLDNLFNSDEDEQ 791

  Fly  1126 CSSVQIHTPPDSNNPSNGGCSAVTNTIEDLKRSTAVASAAVAAAAAAAASGAGNIQAEDLTKMFP 1190
                   ||         |.....|..::...|.....|.:...:.        |...||.:|||
Zfish   792 -------TP---------GARRAVNGADEKFGSKETKPATLDPVSC--------ISTADLHQMFP 832

  Fly  1191 TPPSHEQQHPNSSPCQTDVVMTDLSVDTTTTIITSSITTTCNTTITSSINTTTTACSNPSNSIML 1255
            ||||.||.....||      |...|.|                           .|..|.:.  |
Zfish   833 TPPSLEQHFMGYSP------MNMGSKD---------------------------GCMEPGSG--L 862

  Fly  1256 AAAQAPVTVVAIQTVSKMVKQEYNLELGSPMEEPINDWDYVYRPPQQEKFVGSTRYAPLTNLPSQ 1320
            .|...|.      .:....|.|......||....|.|:.:||:|...:.|||.:.:|||.:||||
Zfish   863 NALDGPT------ALGGPFKIEVEESFCSPKPSEIKDFSFVYKPELCQPFVGCSMFAPLKSLPSQ 921

  Fly  1321 TQPPLTLPTGCFYQPTWSSHKSRAATLAKAAAAQQQQHQKHQALQQRIQLHQQKLQQLQLQNQQQ 1385
            ..||:.||..|.|:|:|:..|........|.....:..:.:...|..||.:..
Zfish   922 CLPPIKLPDECVYRPSWTVGKLELLNSVPAMTIFSKDGENNAMEQDYIQTYTP------------ 974

  Fly  1386 QQAAAAAAAAASGGVGHQKHQHQHLHDLLSAAPRTPLTPSTVPQPLSSGGSQYLLNQLNCPQAPP 1450
                             |.|              ||...::.| |.:||.|
Zfish   975 -----------------QTH--------------TPFLSNSAP-PSNSGTS-------------- 993

  Fly  1451 GASMQQLMHRAGMSPISPGPGMGPYAARSSPMSRATPTHPPPP------YPYDLA-VASPATSTS 1508
                           |.|.|....::| .:|.:..||..|..|      ..|:.: :.|||::.|
Zfish   994 ---------------ILPSPATPRFSA-PTPRTPRTPRTPRGPASVQGSLKYENSDLYSPASTPS 1042

  Fly  1509 SYLNRPLHSQEHPHMHGLGGGATGVVGHGTGGGGHMGMVAYTGDAGIVSGGTAMAAGSSSLLQEL 1573
            :.  |||:|.|                                               .:.:..:
Zfish  1043 TC--RPLNSVE-----------------------------------------------PATVPSI 1058

  Fly  1574 PEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLPGVSFNPFPSG 1638
            ||.:|:.||::|.::.:|:|:|.||||..:||||.      ||:|||.|:|:
Zfish  1059 PEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNM------NIKGADVGIYI------------- 1104

  Fly  1639 AGGALAGQRMLNGPSSAGFGGMRMISAFGGSPASASMPGAGSGHGHGPNGGSNSSSCTPPSSNPH 1703
                       |.|:                 ..|..|
Zfish  1105 -----------NDPN-----------------MEAQYP--------------------------- 1114

  Fly  1704 ITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGIADDPGRNKQPTLLSIIQSLSRKNQ 1768
                       |.||||||||||..:.:|||.|||::|.|...|..:..:
Zfish  1115 -----------CGCGFSAVVNRRYGNGSGLFLEDELDIIGRGSDVSQEAE--------------- 1153

  Fly  1769 NKQGPGETSSALDKIGAGGLPNGQLEQLGHAVFDLLLDQCSIIQTSSSSVHRALQSHRRRMSRQR 1833
             |:.......:|:|.|.||     .:::...:..||.|||    |:..|...||..  ..:|.|
Zfish  1154 -KRFEALRCISLEKTGGGG-----KDRVPDELISLLQDQC----TNPFSPILALDP--EGLSSQ- 1205

  Fly  1834 RIFGNNGAPTASLASIANVLEFMDAHDVISLALEQSRLAFENQRMDNMMDFHGNGSSSSHQQQQL 1898
               |..|........:    |..|.|:...||||..|     |.||||     :|........:.
Zfish  1206 ---GPGGTTVPPCVRV----EERDFHNDCYLALEHGR-----QFMDNM-----SGGKVDEVLVKS 1253

  Fly  1899 TAFHAPPPALRH--KLAGIGAGRLTVHKWPYLPVGFTRSNKEIVRTMNAIQPMLQNAFHCKSRGG 1961
            |..|       |  |.:.:....|              .:::::|.:.::||:||:|...|
Zfish  1254 TCLH-------HWAKRSAVDVSAL--------------CSQDVLRVLLSLQPVLQDAIQKK---- 1293

  Fly  1962 SGSKDASSYNTVSGPLTWRQFHRLAGRAS----GQCEPQPIPSVVVGYEKDWISVAPHSIHYWDK 2022
               :...|:. |.|||||:|||::|||.|    ...||.|||:.:||||.|::.::|..:.||:|
Zfish  1294 ---RTVRSWG-VQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGYEYDFVVLSPFGLPYWEK 1354

  Fly  2023 FLLEPYSYARDVVYVVVCPDNEHVVNCTRSYFRELSSTYEMCKLGKHTPIR--GWDGFLQVGAAR 2085
            .||:|:...|||.|:|:|||::.::...:|:||||::.||.||||:|.||.  ..||.::||.|.
Zfish  1355 LLLDPFGSQRDVGYLVLCPDSDSLLTGAKSFFRELTAVYESCKLGQHRPISKVHADGIVRVGGAA 1419

  Fly  2086 NNVPADRETTPLDDW-LRTLEHAALA-EQIRRYAVAFIHQLAPYLSRVPNDKTLLNPP------- 2141
            ....:::   |::|| |:....::.| .:::.:|....|.|||||:..|.|.:||..|
Zfish  1420 AKKLSEQ---PVNDWFLKAASGSSDAFAKLKLFAQVCRHDLAPYLATQPLDSSLLIQPTPVPSST 1481

  Fly  2142 -------DGSGNSHSK-----GGSSCSSN-----SSSVSGLPGGDLPTDNIKLEPGTEPQVQPME 2189
                   .||.:|:|:     |||:.::|     |:|.|||||.   |:|......:.||...::
Zfish  1482 QSSSSQSSGSASSNSQTSMASGGSALNNNNNSAASNSGSGLPGS---TNNTPSSSSSGPQGSSIQ 1543

  Fly  2190 TNEIKQEPGVGKGGT--------AAGE---TKPTLILGD----------------------PLGM 2221
            :.:....|..|..|.        |.|:   |:.:.:.||                      .:|:
Zfish  1544 SAKPSSFPPFGSMGVQGNSSQSGALGQQAVTQNSSLSGDNSAINSQTQGPSEPPESTMEREKVGV 1608

  Fly  2222 ---GETLEDINPSAIVLYVVNPFTF--ASDSCELERLALIALLRCYAELLKAVPDSVRSQMNIQI 2281
               |::.....|.||::|:|:||::  |...........:.|||||.|:|:|:|..:|:.:.:||
Zfish  1609 PTDGDSHAITYPPAIMIYIVDPFSYEEAEPGTSQSSKWTLGLLRCYLEMLQALPTHIRNSVFVQI 1673

  Fly  2282 ISLESVMELGPCGNRKRFSDEIRCLALNIFSQCRRHLVHAQSVKSLTGFGTAANMEAFLKTKDEP 2346
            :..:.:::......|..::..::.||.::|:||||.|..:.:||||||||....::..|:..|.|
Zfish  1674 VPCQYLLQPVRSEERHLYAQHLKSLAFSVFTQCRRPLPTSTNVKSLTGFGPGLALDTSLRNPDRP 1738

  Fly  2347 NRRAYKMYTAPFVLAPMHERNDKTDFSRSAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDER 2411
              ...::||.||:|||..::..:      .|...|:...:|:|::..||||.||.|||||.||..
Zfish  1739 --ECLRLYTPPFILAPTKDKQTE------LGETFGEASQKYNVLFVGYCLSHDQRWLLATCTDLY 1795

  Fly  2412 GEMLEKICINIDVPNRARRRKAPARYVALKKLMDFIMGIISQTSQMWRLVIGRIGRIGHSELKSW 2476
            ||:||...|::||||||||:|..||.:.|:||.::.:|::..||..||:||||:|||||.||:.|
Zfish  1796 GELLETCIISVDVPNRARRKKGSARKMGLQKLWEWCLGLVQMTSLPWRVVIGRLGRIGHGELRDW 1860

  Fly  2477 SFLLSKQQLQKASKQFKDMCKQCTLMY--PPTILSACLVTLEPDAKLRVMPDQFTPDERFSQ--- 2536
            |.|||::.||..|::.|:.||.|.:..  .|:|||||||.:||.....:|||..:....|.:
Zfish  1861 SILLSRRNLQSVSRRLKENCKLCGISASDTPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTT 1925

  Fly  2537 ISMQ-NPLATPQDVTCTHILVFPTSAVCAPFTRQFQNE-------PQVDDD------FLTFEEEG 2587
            ::|| :.|:||||.:|||||||||||.....:..:.:|       |..|..      |...|:|
Zfish  1926 LNMQTSQLSTPQDTSCTHILVFPTSAFVQVNSSNYTHENIDIAFNPGNDGSDPMGGIFDLLEQE- 1989

  Fly  2588 NEDFSDADIGDLFWDTHMDRVSNHGSPGRMDDNRSWQSAGGNNFKCTPPQEV---EEVGSLNQQP 2649
             .|..|.||.::.  ......|...|||      |....||:..|......:   ||..::.|||
Zfish  1990 -NDLVDPDIINIL--PASPTTSPVHSPG------SQYPHGGDGSKGQSTDRMESHEEAPNILQQP 2045

  Fly  2650 ISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPSIQSADDILNSTNAHQSGNDHP 2714
            :::||.||||..|.:|.|||||||..::.||:|||.:|||||.|:|| |::|:|.::      ||
Zfish  2046 LALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVSSVQS-DELLHSKHS------HP 2103

  Fly  2715 LDSNLTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLY 2761
            ||||.|:||||||||.|||||||..|..|.||.|||||:...|..:|
Zfish  2104 LDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQMY 2150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
skd	NP_730591.2	Med13_N	15..490	CDD:288451	147/508 (29%)
		Med13_C	2234..2755	CDD:283892	225/544 (41%)
med13a	NP_001268397.1	Med13_N	14..384	CDD:288451	147/508 (29%)
		Med13_C	1624..2144	CDD:283892	225/544 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582690
Domainoid	1	1.000	327	1.000	Domainoid score	I1149
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21067
Inparanoid	1	1.050	882	1.000	Inparanoid score	I378
OMA	1	1.010	-	-		QHG46046
OrthoDB	1	1.010	-	-		D177884at2759
OrthoFinder	1	1.000	-	-		FOG0002706
OrthoInspector	1	1.000	-	-		otm24850
orthoMCL	1	0.900	-	-		OOG6_104038
Panther	1	1.100	-	-	O	PTHR48249
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2631
SonicParanoid	1	1.000	-	-		X2492
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.030