DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment syd and SEC3

DIOPT Version :9

Sequence 1:	NP_524652.1	Gene:	syd / 43905	FlyBaseID:	FBgn0024187	Length:	1227	Species:	Drosophila melanogaster
Sequence 2:	NP_010924.1	Gene:	SEC3 / 856726	SGDID:	S000000810	Length:	1336	Species:	Saccharomyces cerevisiae

Alignment Length:	477	Identity:	94/477 - (19%)
Similarity:	171/477 - (35%)	Gaps:	147/477 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 NVLECLDASYRINQEQDVEVELLREDNEQLVTQYEREKSARKQSEQKLLEAEDLAEQENKELATR 138
            :.|..::..|.:.|:|..|...||...||      :....:|::|.|.||.|...:||.::
Yeast   320 STLNEVNKRYELEQQQQQEEAELRRLEEQ------KRLQLQKENEMKRLEEERRIKQEERK---- 374

  Fly   139 LESVESIVRMLELKHKNSLEHASRLEEREADLKKEYNKLHERYTELFKNHVDYMERTKMLMGSTH 203
                    |.:||:|:..||...|..:.|.:.||:                  ||..:.......
Yeast   375 --------RQMELEHQRQLEEEERKRQMELEAKKQ------------------MELKRQRQFEEE 413

  Fly   204 SQMSTASERMDVSRARLNPVARSSGPVSYGFASLENSVMLDTETICSVGSQSDDSGPPSLQNELD 268
            .::....|.:::.|.:               ...|.:..|..|...::..:.::.  .|.:|::|
Yeast   414 QRLKKERELLEIQRKQ---------------REQETAERLKKEEQEALAKKEEEE--KSKRNKVD 461

  Fly   269 NLSGTLERGAATDALQQQHHATSPQSPDSSPVVPN---VPTNVGRSTTKKEQRSDNNLYQELSFQ 330
            |.|.|.|.....|.|.:..:|...:..:::|.:.|   ||.   |||.    |:.:.|.:.|:..
Yeast   462 NESYTQEINGKVDNLLEDLNAVLAEETETTPTMQNGTYVPE---RSTA----RAHDQLKKPLNIA 519

  Fly   331 DNEE---SEENEIVTGSWVHPGEYASSANDNYFGMGKEVENLIMENNELLATKNALNIVKDDLIV 392
            ..|.   |:.|:.:            |.:|...|:  ...||..|:.:   .||.|:..|.|.:.
Yeast   520 KVESLGGSDLNDSI------------SLSDEIAGL--NTSNLSGEDQD---EKNDLSFEKGDEVR 567

  Fly   393 KVDELTGEVEIVREELNAMQQSRTKLRQRISELEDELKKAKEQVKQQNTEQEENDVPLAQRKRFT 457
            ..:...||...|..|::.:|:                                 :.|...:|
Yeast   568 YSNNFEGEAPHVYHEVSIIQE---------------------------------EAPAVSQK--- 596

  Fly   458 RVEMAMVLMERNQYKERLMELQEAVR---------LTEILR---------ASRTVDNLDRKSKQS 504
                 ::|.|.|...|.|:|.:|.::         |.|||.         |...::.:|.:..::
Yeast   597 -----LILPEENNESEALIESKEEIKTMENIDDEVLLEILTDINWSIEDDADSMIERIDLRLAET 656

  Fly   505 IWKYFSNLFT-----PSNRPTE 521
            .:.:..||.:     |:.||.|
Yeast   657 EYLFNQNLLSLQKIGPNIRPYE 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
syd	NP_524652.1	Jnk-SapK_ap_N	43..196	CDD:286787	29/121 (24%)
		JIP_LZII	362..430	CDD:293080	13/67 (19%)
		Vps53_N	374..>524	CDD:282020	31/171 (18%)
SEC3	NP_010924.1	PH_Sec3	82..232	CDD:270125
		PTZ00121	<283..478	CDD:173412	43/210 (20%)
		SMC_N	<348..629	CDD:308206	75/398 (19%)
		ARGLU	<358..444	CDD:405931	24/130 (18%)
		Sec3_C	640..1316	CDD:418729	8/39 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S4832
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950