DRSC/TRiP Functional Genomics Resources

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Protein Alignment syd and MAPK8IP3

DIOPT Version :9

Sequence 1:NP_524652.1 Gene:syd / 43905 FlyBaseID:FBgn0024187 Length:1227 Species:Drosophila melanogaster
Sequence 2:XP_024305969.1 Gene:MAPK8IP3 / 23162 HGNCID:6884 Length:1395 Species:Homo sapiens


Alignment Length:1493 Identity:567/1493 - (37%)
Similarity:744/1493 - (49%) Gaps:391/1493 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 QSGAETVYGTED--NNMVMSEKNEQVVSIVQQLAGSIYQEFERMINRYDEDVVKNLMPLLVNVLE 77
            :.|...|| .:|  :..||||:       |..||||||:||||:|:.|||:|||.||||:|||||
Human     8 EGGGVVVY-QDDYCSGSVMSER-------VSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLE 64

  Fly    78 CLDASYRINQEQDVEVELLREDNEQLVTQYEREKSARKQSEQKLLEAEDLAEQENKELATRLESV 142
            .||:....|||.:||:||||||||||:|||||||:.|:|:|:|.:|.||..|||.|||..::|..
Human    65 NLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHY 129

  Fly   143 ESIVRMLELKHKNSLEHASRLEEREADLKKEYNKLHERYTELFKNHVDYMERTKMLM----GSTH 203
            |...|.||||.||..:..|||||||:::|||||.||:|:||:.:.:|:::||:||..    ..|.
Human   130 EFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTE 194

  Fly   204 SQMSTASERMDVSRARL-NPVARSSGPVSYGFASLENSVML----DTETICSVGSQSDDSGPPSL 263
            |.:...|.|....::|. .|.:.:..|::.|....:....|    |...:..:|.....|.....
Human   195 SSLPGRSPRQSWRKSRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCP 259

  Fly   264 QNELDNLSGTLERGAATDALQQQHHATSPQSPDSS-PVVPNVPTN----------VGRSTTK--K 315
            |:|:.      |.|.::.|.......|...:|.|| |.....|.|          ||...:|  :
Human   260 QDEMS------ESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAR 318

  Fly   316 EQRSDNNLYQELSFQ----------DNEESEENEIV----------------------------- 341
            |:|...|:..:::.:          .:|.|:..:|:                             
Human   319 EKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKA 383

  Fly   342 ----TGSWVHP-------------------GEYASSANDNYFGMGKEVENLIMENNELLATKNAL 383
                |.|..|.                   ||:  |..|::|||||||.||::||::||.|||||
Human   384 FGINTDSLYHELSTAGSEVIGDVDEGADLLGEF--SVRDDFFGMGKEVGNLLLENSQLLETKNAL 446

  Fly   384 NIVKDDLIVKVDELTGEVEIVREELNAMQQSRTKLRQRISELEDELKKAKEQ--VKQQNTEQEEN 446
            |:||:|||.|||:|:||.|::|.||.|.:|::.||..||.|||:|||:.|.:  :.::..::|..
Human   447 NVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAE 511

  Fly   447 DV-----------PLAQRKRFTRVEMAMVLMERNQYKERLMELQEAVRLTEILRASRTVDNLDRK 500
            ||           |:|||:||||||||.||||||||||||||||||||.||::||||...::..|
Human   512 DVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEK 576

  Fly   501 SKQSIWKYFSNLFTPSNR--PTERVADGLGGGPMFRHTGGGSPAHSHGSPSRGSGGGDNRLALTS 563
            .|.:||::||.||:.|:.  |.:|....:........|.|.|...:|.                 
Human   577 KKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSPTTAGFSQRRNHA----------------- 624

  Fly   564 GQPPVHPASAGLANALIMPKDYAEEGSSERISARR---REQYRQLRAHVQKEDGRLHAYGWSLPI 625
                :.|.|||.......|.|....      ||||   ||||||:|.||:.:||||.|.|||||.
Human   625 ----MCPISAGSRPLEFFPDDDCTS------SARREQKREQYRQVREHVRNDDGRLQACGWSLPA 679

  Fly   626 NKASQEANPNRHSGG--------VPVPVYCNPLAEASPHMKVFCAAGVNLHG-----GFTKNGQS 677
            .  .::.:||   ||        |||||||.||.|..|.||::|||||||.|     ....||..
Human   680 K--YKQLSPN---GGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRPNEDDAGNGVK 739

  Fly   678 LIPANSPYA--------PKSTLKIAEITSPTADQSMEALDRQMARVSLETLEPETQ-LSSFVWIC 733
            ..|...|..        |||.     .|||...::.|.              ||.. .||.|||.
Human   740 PAPGRDPLTCDREGDGEPKSA-----HTSPEKKKAKEL--------------PEMDATSSRVWIL 785

  Fly   734 TSTHAASTVSVVDANQSATVLDAFPICASHLLCIASVQGAMESDYALLEQSEVVKAGEML----- 793
            |||...|.|.::||||..||:|.|.:|.:|:|||:|:..|.:|||         ..|||.     
Human   786 TSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDY---------PPGEMFLDSDV 841

  Fly   794 --QRPG-----EGTELLGKVEFVRVKPKS-----------DDEQ-------NSNEKQQQEEEEAK 833
              :.||     .|..|:|......| |:|           |..|       |......|..|||.
Human   842 NPEDPGADGVLAGITLVGCATRCNV-PRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEAT 905

  Fly   834 EATEKSNEQLPAVSAEEPLGNVEAIKIRQPLPGA--------PQRLSTDGNQTNNNNNSSSSSNL 890
            ||||     :|.....||    |...:|   ||.        |....:.|.|..:.|.....|: 
Human   906 EATE-----VPDPGPSEP----ETATLR---PGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSS- 957

  Fly   891 LFATKSLNPILETKDRDEP------AMSSVGPTMWLGAQDGWLYVHSSVGRWHECLHRVLLPDAV 949
                       .|:...||      |.||..||||||||:|||||||:|..|.:|||.:.|.|:|
Human   958 -----------STRPEPEPSGDPTGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSV 1011

  Fly   950 LAIVHVEARVVVALANAQLAVFRRQTDGQWDLNSYHLVTLGDRNHSIRCLCVAGERIWAAHRNKI 1014
            |::|||:.||:||||:..||:|.|..||||||::|||:.||..:|||||:.|..:|:|..::||:
Human  1012 LSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKV 1076

  Fly  1015 FIVDPVSLNIVHSLDAHPRKESQVRQMAATGAGVWVSIRLDSTLRLYNTHTFEHKQDVDIEPYVS 1079
            .::.|.::.|..|.|||||:||||||:|..|.|||||||||||||||:.||.:|.||||||||||
Human  1077 HVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVS 1141

  Fly  1080 KMLGTGKLGFSFVRITALMVSCNRLWIGTSNGVIISVPLAE------------------------ 1120
            ||||||||||||||||||:|:.:|||:||.|||:||:||.|                        
Human  1142 KMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPLTESEWPAHLQGQWCCQRCTWVHGVAL 1206

  Fly  1121 -------------------------------------VQPKSSSDPHGQ---------------- 1132
                                                 ::...:|...|:                
Human  1207 QGHLGGCLAAPTLTALLFSHAPPMSPAVVLHRGQLLGLRANKTSPTSGEGARPGGIIHVYGDDSS 1271

  Fly  1133 -------MPLCCMANAQLSFHGHRDAVKFFVSVPMLQQPNLNGGLTFT----------------N 1174
                   :|.|.||.|||.|||||||||||||||......|||.:..:                .
Human  1272 DRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPAEGPGPAAPASEVEGQ 1336

  Fly  1175 KRPDMLVMCGGEGYIDFRINDNDMENSIQLEPNQTIENRGD------------KSYLIVWHVS 1225
            |..::||:.||||||||||.|.        |.::|.|..||            :|::|||.||
Human  1337 KLRNVLVLSGGEGYIDFRIGDG--------EDDETEEGAGDMSQVKPVLSKAERSHIIVWQVS 1391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sydNP_524652.1 Jnk-SapK_ap_N 43..196 CDD:286787 92/152 (61%)
JIP_LZII 362..430 CDD:293080 42/67 (63%)
Vps53_N 374..>524 CDD:282020 88/164 (54%)
MAPK8IP3XP_024305969.1 Jnk-SapK_ap_N 30..183 CDD:313040 92/152 (61%)
JIP_LZII 425..493 CDD:318633 42/67 (63%)
SMC_N <436..>562 CDD:330553 72/125 (58%)
Trypan_PARP 858..980 CDD:114603 34/146 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159214
Domainoid 1 1.000 611 1.000 Domainoid score I187
eggNOG 1 0.900 - - E1_KOG2077
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 874 1.000 Inparanoid score I416
Isobase 1 0.950 - 0.917438 Normalized mean entropy S4832
OMA 1 1.010 - - QHG49339
OrthoDB 1 1.010 - - D165438at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41420
orthoMCL 1 0.900 - - OOG6_104719
Panther 1 1.100 - - LDO PTHR13886
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4614
SonicParanoid 1 1.000 - - X2032
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.750

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