Protein Alignment syd and mapk8ip3

DIOPT Version :9

• Sequence 1: NP_524652.1
• Gene: syd / 43905
• FlyBaseID: FBgn0024187
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: NP_001289173.1
• Gene: mapk8ip3 / 100318355
• ZFINID: ZDB-GENE-090303-6
• Length: 1299
• Species: Danio rerio
• Alignment Length: 1412
• Identity: 550/1412 - (38%)
• Similarity: 753/1412 - (53%)
• Gaps: 326/1412 - (23%)

  Fly    19 ETVYGTEDNNMVMSEKNEQVVSIVQQLAGSIYQEFERMINRYDEDVVKNLMPLLVNVLECLDASY 83
            |.||  :|:...:|..:|:|..    ||.||||||||:|..|||:|||.||||:|||||.||:..
Zfish     5 EVVY--QDDYGAVSVMSERVTG----LASSIYQEFERLIKTYDEEVVKELMPLVVNVLENLDSVL 63

  Fly    84 RINQEQDVEVELLREDNEQLVTQYEREKSARKQSEQKLLEAEDLAEQENKELATRLESVESIVRM 148
            ..|||.:||:|||:||||||:|||||||:.|||:|:|.:|.||..|.:.|:|.|.:|::|...:.
Zfish    64 TENQEHEVELELLKEDNEQLITQYEREKALRKQAEEKFIEFEDALEADKKDLQTTVETLELQAKQ 128

  Fly   149 LELKHKNSLEHASRLEEREADLKKEYNKLHERYTELFKNHVDYMERTKMLMGSTHSQMSTASERM 213
            ||||.||..:..|||||||:|:|||||.||:|:||:.:.:|:::||:|:....::...||...|.
Zfish   129 LELKSKNYADQISRLEERESDMKKEYNALHQRHTEMIQTYVEHIERSKLQQSGSNQSESTGCGRS 193

  Fly   214 DVSRARLNPVARSSGPVSYGFASLENSVMLDTETICSVGSQSDDSGPPSLQNELDNLSGTLERGA 278
            .....|.:...|                                  ||||  .|......:|.|:
Zfish   194 QRHNWRKSKTER----------------------------------PPSL--SLYPGGDGMEDGS 222

  Fly   279 ATDALQQQHHATSPQSPDSSPVVPN---VPTN-----VGRSTTK----KEQRSDNNLYQELSFQD 331
            .:|::.....:|..:|...:..||:   .|.|     ||...|.    :::|:...|.:.:..|.
Zfish   223 DSDSVAATPSSTGSKSNTPTSSVPSATVTPLNDGLVSVGEYDTSRGRARDRRTGKRLSRNMEVQV 287

  Fly   332 NEE--------------SEENEIV---------------------------------TGSWVHP- 348
            ::|              ||..||:                                 |.|..|.
Zfish   288 SQETRNVSIGMGSSDEWSEFQEIIDSTPELDMCLDPRIFGGGNSPSQGIVNEAFGINTDSLYHEI 352

  Fly   349 ------------------GEYASSANDNYFGMGKEVENLIMENNELLATKNALNIVKDDLIVKVD 395
                              ||:  |..|::||||||||||:.||.:||.|||||||||:|||.|||
Zfish   353 KDAKSDIIGDVDAGAELLGEF--SVRDDFFGMGKEVENLLTENKQLLETKNALNIVKNDLIAKVD 415

  Fly   396 ELTGEVEIVREELNAMQQSRTKLRQRISELEDELKKAKEQV--KQQNTEQE---------ENDVP 449
            ||:.|.|::||||.:::||:||:.||:.|||:|||:.:.:.  ..|:::.|         ::||.
Zfish   416 ELSSEQEVLREELESVKQSKTKVDQRVKELEEELKRLRAEALGASQDSKDEGGEDYSSPLQDDVT 480

  Fly   450 LAQRKRFTRVEMAMVLMERNQYKERLMELQEAVRLTEILRASRTVDNLDRKSKQSIWKYFSNLFT 514
            :.||:|||:||||.||||||||||||||||||||.||::||||....|..|.|..||::|:.||:
Zfish   481 MTQRRRFTQVEMARVLMERNQYKERLMELQEAVRWTEMIRASRESPPLPEKKKSIIWQFFARLFS 545

  Fly   515 PSNRPTERVADGLGGGPMFR-------HTGGGSPAHSHGSPSRGSGGGDNRLALTSGQPPVHPAS 572
            .|..|.          |:.|       |....|||           |.:.|.:.|..|
Zfish   546 SSASPP----------PVKRPYTSVNIHYKSPSPA-----------GYNQRRSQTMCQ------- 582

  Fly   573 AGLANALIMPKDYAEEGSSERISAR--RREQYRQLRAHVQKEDGRLHAYGWSLPI---------- 625
              ::.:..: :::..|..|...:.|  |||||||:|.|::::||.:...|||:|.
Zfish   583 --ISTSTCI-REFLPEDDSALCTRREQRREQYRQVREHMRRKDGPMQTCGWSVPSRLKQNGCQAD 644

  Fly   626 ---------NKASQEANPNRHSGGVPVPVYCNPLAEASPHMKVFCAAGVNLHGGFTKNGQ--SLI 679
                     |:|: |...||.. .|||||||.||.|..|:.|::|||||:|.|..|.:.:  |:.
Zfish   645 SAPDATAKRNQAT-EKEDNRMK-NVPVPVYCRPLVEKDPNRKLWCAAGVDLTGWKTSSQEAASVK 707

  Fly   680 PANSPYAPKSTLKIAEITSP-TADQSMEALDRQMARVSLETLEP----ETQ-LSSFVWICTSTHA 738
            |:|.             :.| ||:.  |..|.:..:.|.|..:|    ||. :||.|||.||||:
Zfish   708 PSNG-------------SDPLTAEN--EGGDGKSEQSSPEKKKPKELHETDPVSSRVWILTSTHS 757

  Fly   739 ASTVSVVDANQSATVLDAFPICASHLLCIASVQGAMESDYALLEQSEVVKAGEML--QRPGEG-T 800
            ||.|.::|||...:::|.|.:|.:|:|||:||..|.||||         .|||:.  |:.|:| :
Zfish   758 ASKVVIIDANLPCSLVDQFNVCNAHVLCISSVPAASESDY---------PAGEIFLEQQAGDGAS 813

  Fly   801 ELLGKVEFV----------------------RVKPKSDDEQNS-------NEKQQQEEEEAKEAT 836
            |..|.||.:                      |......|..|:       :....|..|||.||.
Zfish   814 EEKGGVEGMLAGITIVGCATNCSVVRSNCSSRTDTPVQDRSNAPTAPVCRSLAVSQSAEEATEAI 878

  Fly   837 EKSNEQLPAVSAEEPLGNVEAIKIRQPLPGAPQRLSTDGNQTNNNNNSSSSSNLLFATKSLNPIL 901
            |.:.|..|:.:|:..||:.            .:.:.||        |:.|...:.....|..|..
Zfish   879 EVTEEAGPSENADSTLGSF------------TEHVFTD--------NTHSEPGVAKEKVSSAPAD 923

  Fly   902 ETKDRDEPAMSSVGPTMWLGAQDGWLYVHSSVGRWHECLHRVLLPDAVLAIVHVEARVVVALANA 966
            ..:..||.|.:|..||||||||:|||||||:|..|.:|||.:.|.|:||::|||:.||:||||:.
Zfish   924 SEEAADERAGTSAAPTMWLGAQNGWLYVHSAVSNWKKCLHSIKLKDSVLSLVHVKGRVLVALADG 988

  Fly   967 QLAVFRRQTDGQWDLNSYHLVTLGDRNHSIRCLCVAGERIWAAHRNKIFIVDPVSLNIVHSLDAH 1031
            .||:|.|..||||||::|||:.||..:|||||:.|..:::|..::|||.::.|.|:.|..|.|||
Zfish   989 TLAIFHRSEDGQWDLSNYHLMDLGRPHHSIRCMAVVHDKVWCGNKNKIHVIQPKSMQIEKSFDAH 1053

  Fly  1032 PRKESQVRQMAATGAGVWVSIRLDSTLRLYNTHTFEHKQDVDIEPYVSKMLGTGKLGFSFVRITA 1096
            |||||||||:|..|.|||||||||||||||:.||.:|.|||||||||||||||||||||||||||
Zfish  1054 PRKESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITA 1118

  Fly  1097 LMVSCNRLWIGTSNGVIISVPLAE----------------VQPKSS------------SDPHGQM 1133
            |::..||||:||.||||||:||.|                |.|.||            |:....:
Zfish  1119 LLIGGNRLWVGTGNGVIISIPLTETVVLHRGQLLGLRANKVSPTSSGGVIHVYADDSTSEKSSFI 1183

  Fly  1134 PLCCMANAQLSFHGHRDAVKFFVSVPMLQQPNLNGGL---------------TFTNKRPDMLVMC 1183
            |.|.||.|||.|||||||||||||||......|||.:               |......::||:.
Zfish  1184 PYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPSESQGSSAPAETEAQSLQNVLVLS 1248

  Fly  1184 GGEGYIDFRINDNDMENSIQLEPNQTIE-----NRGDKSYLIVWHVS 1225
            ||||||||||.|.:.:.:.:.:.::..:     ::.::|::|||.||
Zfish  1249 GGEGYIDFRIGDGEDDETEEADDDEAPQMKPALSKAERSHIIVWQVS 1295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
syd	NP_524652.1	Jnk-SapK_ap_N	43..196	CDD:286787	90/152 (59%)
		JIP_LZII	362..430	CDD:293080	45/67 (67%)
		Vps53_N	374..>524	CDD:282020	86/160 (54%)
mapk8ip3	NP_001289173.1	Jnk-SapK_ap_N	24..176	CDD:286787	90/155 (58%)
		TPR_MLP1_2	54..160	CDD:285204	62/105 (59%)
		JIP_LZII	382..450	CDD:293080	45/67 (67%)
		Uso1_p115_C	392..513	CDD:282695	69/120 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595322
Domainoid	1	1.000	567	1.000	Domainoid score	I223
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	798	1.000	Inparanoid score	I484
OMA	1	1.010	-	-		QHG49339
OrthoDB	1	1.010	-	-		D165438at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25756
orthoMCL	1	0.900	-	-		OOG6_104719
Panther	1	1.100	-	-	LDO	PTHR13886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17302
SonicParanoid	1	1.000	-	-		X2032
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.940