Protein Alignment syd and mapk8ip3

DIOPT Version :10

• Sequence 1: NP_524652.1
• Gene: syd / 43905
• FlyBaseID: FBgn0024187
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: XP_073791085.1
• Gene: mapk8ip3 / 100318355
• ZFINID: ZDB-GENE-090303-6
• Length: 1342
• Species: Danio rerio
• Alignment Length: 1453
• Identity: 559/1453 - (38%)
• Similarity: 762/1453 - (52%)
• Gaps: 343/1453 - (23%)

  Fly     1 MMDNDDALLNNGGPQSGAETVYGTEDNNMVMSEKNEQVVSIVQQLAGSIYQEFERMINRYDEDVV 65
            ||:.|:.:..:.         ||...   ||||:       |..||.||||||||:|..|||:||
Zfish     1 MMELDEVVYQDD---------YGAVS---VMSER-------VTGLASSIYQEFERLIKTYDEEVV 46

  Fly    66 KNLMPLLVNVLECLDASYRINQEQDVEVELLREDNEQLVTQYEREKSARKQSEQKLLEAEDLAEQ 130
            |.||||:|||||.||:....|||.:||:|||:||||||:|||||||:.|||:|:|.:|.||..|.
Zfish    47 KELMPLVVNVLENLDSVLTENQEHEVELELLKEDNEQLITQYEREKALRKQAEEKFIEFEDALEA 111

  Fly   131 ENKELATRLESVESIVRMLELKHKNSLEHASRLEEREADLKKEYNKLHERYTELFKNHVDYMERT 195
            :.|:|.|.:|::|...:.||||.||..:..|||||||:|:|||||.||:|:||:.:.:|:::||:
Zfish   112 DKKDLQTTVETLELQAKQLELKSKNYADQISRLEERESDMKKEYNALHQRHTEMIQTYVEHIERS 176

  Fly   196 KMLMGSTHSQMSTASERMDVSRARLNPVAR--------------SSGPVSYGFASLENSVMLDTE 246
            |:....::...||...|......|.:...|              ..||   |.|.:.:|
Zfish   177 KLQQSGSNQSESTGCGRSQRHNWRKSKAERPPSLSLYPGGDGMVRGGP---GGARMVSS------ 232

  Fly   247 TICSVGSQSDDSGP---PSLQNELDNLSGTLERGAATDALQQQHHATSPQSPDSSPVVPN---VP 305
               .:...||.|.|   |..|          |.|:.:|::.....:|..:|...:..||:   .|
Zfish   233 ---DIWHSSDLSRPVYAPGYQ----------EDGSDSDSVAATPSSTGSKSNTPTSSVPSATVTP 284

  Fly   306 TNVGRSTT---------KKEQRSDNNLYQELSFQDNEE--------------SEENEIV------ 341
            .|.|..:.         .:::|:...|.:.:..|.::|              ||..||:
Zfish   285 LNDGLVSVGEYDPSRGRARDRRTGKRLSRNMEVQVSQETRNVSIGMGSSDEWSEFQEIIDSTPEL 349

  Fly   342 ---------------------------TGSWVHP-------------------GEYASSANDNYF 360
                                       |.|..|.                   ||:  |..|::|
Zfish   350 DMCLDPRIFGGGNSPSQGIVNEAFGINTDSLYHEIKDAKSDIIGDVDAGAELLGEF--SVRDDFF 412

  Fly   361 GMGKEVENLIMENNELLATKNALNIVKDDLIVKVDELTGEVEIVREELNAMQQSRTKLRQRISEL 425
            |||||||||:.||.:||.|||||||||:|||.|||||:.|.|::||||.:::||:||:.||:.||
Zfish   413 GMGKEVENLLTENKQLLETKNALNIVKNDLIAKVDELSSEQEVLREELESVKQSKTKVDQRVKEL 477

  Fly   426 EDELKKAKEQV--KQQNTEQE---------ENDVPLAQRKRFTRVEMAMVLMERNQYKERLMELQ 479
            |:|||:.:.:.  ..|:::.|         ::||.:.||:||||||||.||||||||||||||||
Zfish   478 EEELKRLRAEALGASQDSKDEGGEDYSSPLQDDVTMTQRRRFTRVEMARVLMERNQYKERLMELQ 542

  Fly   480 EAVRLTEILRASRTVDNLDRKSKQSIWKYFSNLFTPSNRPTERVADGLGGGPMFR-------HTG 537
            ||||.||::||||....|..|.|..||::|:.||:.|..|.          |:.|       |..
Zfish   543 EAVRWTEMIRASRESPPLPEKKKSIIWQFFARLFSSSASPP----------PVKRPYTSVNIHYK 597

  Fly   538 GGSPAHSHGSPSRGSGGGDNRLALTSGQPPVHPASAGLANALIMPKDYAEEGSSERIS------- 595
            ..|||           |.:.|.:.|..|     .|........:|::....|.:..:|
Zfish   598 SPSPA-----------GYNQRRSQTMCQ-----ISTSTCIREFLPEEMPVNGVASLLSDSALCTR 646

  Fly   596 -ARRREQYRQLRAHVQKEDGRLHAYGWSLPI-------------------NKASQEANPNRHSGG 640
             .:|||||||:|.|::::||.:...|||:|.                   |:|: |...||.. .
Zfish   647 REQRREQYRQVREHMRRKDGPMQTCGWSVPSRLKQNGCQADSAPDATAKRNQAT-EKEDNRMK-N 709

  Fly   641 VPVPVYCNPLAEASPHMKVFCAAGVNLHGGFTKNGQ--SLIPANSPYAPKSTLKIAEITSP-TAD 702
            |||||||.||.|..|:.|::|||||:|.|..|.:.:  |:.|:|.             :.| ||:
Zfish   710 VPVPVYCRPLVEKDPNRKLWCAAGVDLTGWKTSSQEAASVKPSNG-------------SDPLTAE 761

  Fly   703 QSMEALDRQMARVSLETLEP----ETQ-LSSFVWICTSTHAASTVSVVDANQSATVLDAFPICAS 762
            .  |..|.:..:.|.|..:|    ||. :||.|||.||||:||.|.::|||...:::|.|.:|.:
Zfish   762 N--EGGDGKSEQSSPEKKKPKELHETDPVSSRVWILTSTHSASKVVIIDANLPCSLVDQFNVCNA 824

  Fly   763 HLLCIASVQGAMESDYALLEQSEVVKAGEML--QRPGEG-TELLGKVEFV--------------- 809
            |:|||:||..|.||||         .|||:.  |:.|:| :|..|.||.:
Zfish   825 HVLCISSVPAASESDY---------PAGEIFLEQQAGDGASEEKGGVEGMLAGITIVGCATNCSV 880

  Fly   810 -------RVKPKSDDEQNS-------NEKQQQEEEEAKEATEKSNEQLPAVSAEEPLGNVEAIKI 860
                   |......|..|:       :....|..|||.||.|.:.|..|:.:|:..||:.
Zfish   881 VRSNCSSRTDTPVQDRSNAPTAPVCRSLAVSQSAEEATEAIEVTEEAGPSENADSTLGSF----- 940

  Fly   861 RQPLPGAPQRLSTDGNQTNNNNNSSSSSNLLFATKSLNPILETKDRDEPAMSSVGPTMWLGAQDG 925
                   .:.:.||        |:.|...:.....|..|....:..||.|.:|..||||||||:|
Zfish   941 -------TEHVFTD--------NTHSEPGVAKEKVSSAPADSEEAADERAGTSAAPTMWLGAQNG 990

  Fly   926 WLYVHSSVGRWHECLHRVLLPDAVLAIVHVEARVVVALANAQLAVFRRQTDGQWDLNSYHLVTLG 990
            ||||||:|..|.:|||.:.|.|:||::|||:.||:||||:..||:|.|..||||||::|||:.||
Zfish   991 WLYVHSAVSNWKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRSEDGQWDLSNYHLMDLG 1055

  Fly   991 DRNHSIRCLCVAGERIWAAHRNKIFIVDPVSLNIVHSLDAHPRKESQVRQMAATGAGVWVSIRLD 1055
            ..:|||||:.|..:::|..::|||.::.|.|:.|..|.||||||||||||:|..|.|||||||||
Zfish  1056 RPHHSIRCMAVVHDKVWCGNKNKIHVIQPKSMQIEKSFDAHPRKESQVRQLAWIGDGVWVSIRLD 1120

  Fly  1056 STLRLYNTHTFEHKQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWIGTSNGVIISVPLAE 1120
            ||||||:.||.:|.||||||||||||||||||||||||||||::..||||:||.||||||:||.|
Zfish  1121 STLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITALLIGGNRLWVGTGNGVIISIPLTE 1185

  Fly  1121 ----------------VQPKSS------------SDPHGQMPLCCMANAQLSFHGHRDAVKFFVS 1157
                            |.|.||            |:....:|.|.||.|||.|||||||||||||
Zfish  1186 TVVLHRGQLLGLRANKVSPTSSGGVIHVYADDSTSEKSSFIPYCSMAQAQLCFHGHRDAVKFFVS 1250

  Fly  1158 VPMLQQPNLNGGL---------------TFTNKRPDMLVMCGGEGYIDFRINDNDMENSIQLEPN 1207
            ||......|||.:               |......::||:.||||||||||.|.:.:.:.:.:.:
Zfish  1251 VPGNVLATLNGSVLDSPSESQGSSAPAETEAQSLQNVLVLSGGEGYIDFRIGDGEDDETEEADDD 1315

  Fly  1208 QTIE-----NRGDKSYLIVWHVS 1225
            :..:     ::.::|::|||.||
Zfish  1316 EAPQMKPALSKAERSHIIVWQVS 1338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
syd	NP_524652.1	Jnk-SapK_ap_N	42..197	CDD:462875	91/154 (59%)
		SCP-1	<87..>475	CDD:114219	176/493 (36%)
		JIP_LZII	362..430	CDD:465127	45/67 (67%)
		WD40_2	906..>1157	CDD:465964	164/278 (59%)
mapk8ip3	XP_073791085.1	None