Protein Alignment AMPKalpha and BRSK2

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_054189097.1
• Gene: BRSK2 / 9024
• HGNCID: 11405
• Length: 895
• Species: Homo sapiens
• Alignment Length: 736
• Identity: 209/736 - (28%)
• Similarity: 316/736 - (42%)
• Gaps: 237/736 - (32%)

  Fly    11 AVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRR 75
            |.||..|.|:.|               ..|.||:|.|.:|..|||:||:||:|: |..|:.|:.|
Human    32 APAAPKAEGRAL---------------RAGLVKLGVHCVTCQKVAIKIVNREKL-SESVLMKVER 80

  Fly    76 EIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVD 140
            ||..|||..|||::||:.|......:::::|:|||||||||:||.|:|...:||:||:||||.:|
Human    81 EIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALD 145

  Fly   141 YCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGP 205
            :||.|.|.||||||||||||...:::|||||::::.:....|.||||||:||.||||.|:.|.|.
Human   146 FCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGR 210

  Fly   206 EVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRAN 270
            :.|:|||||||:|||.|.|||||:::..|..|:|.|:|.:|.::.....:|:..|::||..:|..
Human   211 KADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLT 275

  Fly   271 IEEIKKHEWF---------QKDLPAYL----FPSSIEQDSNVIDT-YAVAEVCTKFGVKETEVHN 321
            :|.|:||.|:         ::.:|..:    .||..:.|.:|:|: :::.  |.:   ...::..
Human   276 LEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLG--CFR---DRNKLLQ 335

  Fly   322 SLLSGDPHDQLAIAYHLIIDNK-RFADD------AANQIN------------------------E 355
            .||| :..:|..:.|.|::|.| |:...      ..|:|:                        |
Human   336 DLLS-EEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSME 399

  Fly   356 INNFFVAGSPPP----------------------------------------------------- 367
            :.:....|||.|
Human   400 VLSVTDGGSPVPARRAIEMAQHGQSKAMFSKSLDIAEAHPQFSKEDRSRSISGASSGLSTSPLSS 464

  Fly   368 ---------PPPPPVP------------------QSSMDHQAPL----------------ATVT- 388
                     |||||.|                  .|...|..||                |.:|
Human   465 PRPIRKLVLPPPPPEPPFVARPLATSTEPEACGSASRPGHVLPLQAALRPDPKTQTLPCKAKLTD 529

  Fly   389 --VGGGTSASSGTATPV-PPVAG---------GTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGG 441
              :.|..|.....:||. ||..|         |.|:..:|.||.|..|.|  :.:...::|.:
Human   530 KPLQGTKSNPFPASTPARPPATGLCPQLAPPLGPPALRVPPRPPPAGIEP--NTKSVPTIQVT-- 590

  Fly   442 GAFPEKTARG-------GTPIKRAKWH-LGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRV 498
               |..:.||       |||:...|.. .|..:.:.|:        :.......|        |.
Human   591 ---PHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPS--------SPSVGGVPW--------RA 636

  Fly   499 RRQNVKTG-----KFSKMSLQL--------------YQVDAKSYLLDFKSLTNDE---VEQGD-- 539
            |..::|..     :|.:..||:              .::..||:..:|.||..:|   |...|
Human   637 RLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKDKP 701

  Fly   540 ------DVIMESLTPPPLSVS 554
                  |::...|:.|.||.|
Human   702 LSSIKADIVHAFLSIPSLSHS 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	121/254 (48%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	15/94 (16%)
		AMPKA_C	457..580	CDD:213378	24/129 (19%)
BRSK2	XP_054189097.1	STKc_BRSK1_2	46..285	CDD:270983	121/239 (51%)
		UBA_BRSK	312..365	CDD:270525	13/58 (22%)