DRSC/TRiP Functional Genomics Resources

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Protein Alignment AMPKalpha and BRSK2

DIOPT Version :9

Sequence 1:NP_477313.1 Gene:AMPKalpha / 43904 FlyBaseID:FBgn0023169 Length:582 Species:Drosophila melanogaster
Sequence 2:XP_016874022.1 Gene:BRSK2 / 9024 HGNCID:11405 Length:880 Species:Homo sapiens


Alignment Length:722 Identity:210/722 - (29%)
Similarity:317/722 - (43%) Gaps:222/722 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHII 89
            :|.|.|..|||.|..|.||:|.|.:|..|||:||:||:|: |..|:.|:.|||..|||..|||::
Human    16 VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPHVL 79

  Fly    90 KLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKP 154
            ||:.|......:::::|:|||||||||:||.|:|...:||:||:||||.:|:||.|.|.||||||
Human    80 KLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKP 144

  Fly   155 ENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYAL 219
            ||||||...:::|||||::::.:....|.||||||:||.||||.|:.|.|.:.|:|||||||:||
Human   145 ENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFAL 209

  Fly   220 LCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWF---- 280
            |.|.|||||:::..|..|:|.|:|.:|.::.....:|:..|::||..:|..:|.|:||.|:    
Human   210 LVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGK 274

  Fly   281 -----QKDLPAYL----FPSSIEQDSNVIDT-YAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIA 335
                 ::.:|..:    .||..:.|.:|:|: :::.  |.:   ...::...||| :..:|..:.
Human   275 NEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLG--CFR---DRNKLLQDLLS-EEENQEKMI 333

  Fly   336 YHLIIDNK-RFADD------AANQIN------------------------EINNFFVAGSPPP-- 367
            |.|::|.| |:...      ..|:|:                        |:.:....|||.|  
Human   334 YFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPAR 398

  Fly   368 ------------------------------------------------------------PPPPP 372
                                                                        |||||
Human   399 RAIEMAQHGQSKAMFSKSLDIAEAHPQFSKEDRSRSISGASSGLSTSPLSSPRPIRKLVLPPPPP 463

  Fly   373 VP------------------QSSMDHQAPL----------------ATVT---VGGGTSASSGTA 400
            .|                  .|...|..||                |.:|   :.|..|.....:
Human   464 EPPFVARPLATSTEPEACGSASRPGHVLPLQAALRPDPKTQTLPCKAKLTDKPLQGTKSNPFPAS 528

  Fly   401 TPV-PPVAG---------GTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARG---- 451
            ||. ||..|         |.|:..:|.||.|..|.|  :.:...::|.:     |..:.||    
Human   529 TPARPPATGLCPQLAPPLGPPALRVPPRPPPAGIEP--NTKSVPTIQVT-----PHPSPRGSPLP 586

  Fly   452 ---GTPIKRAKWH-LGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTG-----K 507
               |||:...|.. .|..:.:.|:        :.......|        |.|..::|..     :
Human   587 TPKGTPVHTPKESPAGTPNPTPPS--------SPSVGGVPW--------RARLNSIKNSFLGSPR 635

  Fly   508 FSKMSLQL--------------YQVDAKSYLLDFKSLTNDE---VEQGD--------DVIMESLT 547
            |.:..||:              .::..||:..:|.||..:|   |...|        |::...|:
Human   636 FHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKDKPLSSIKADIVHAFLS 700

  Fly   548 PPPLSVS 554
            .|.||.|
Human   701 IPSLSHS 707

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AMPKalphaNP_477313.1 STKc_AMPK_alpha 25..280 CDD:270981 128/254 (50%)
UBA_AID_AMPKalpha 297..360 CDD:270521 15/94 (16%)
AMPKA_C 457..580 CDD:213378 24/129 (19%)
BRSK2XP_016874022.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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