DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and SKS1

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_015299.1	Gene:	SKS1 / 856081	SGDID:	S000005947	Length:	502	Species:	Saccharomyces cerevisiae

Alignment Length:	255	Identity:	77/255 - (30%)
Similarity:	121/255 - (47%)	Gaps:	54/255 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 REIQ-NLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELF------DYIVKHGKLQEHQARRFF 132
            |||. .|::..|.:|:|::||:.:....|::|:|.. .:||      .:.|.||.|    .::.|
Yeast   108 REIAFQLRVQSHGNIVKIHQVLESSIATFIVMDYYD-RDLFTSIVDDKHFVNHGIL----IKKVF 167

  Fly   133 QQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTS-C-GSPNYAAPE 195
            .|:.|.:|:|||..|.|.|:||||:|||.|.:..:.|||||.   ..::|..: | ||..|.|||
Yeast   168 LQLCSALDHCHRLGIYHCDIKPENVLLDRNDNAYLCDFGLST---KSKYLAPNVCVGSSYYMAPE 229

  Fly   196 VISGKLYA------GPEV------------DIWSCGVILYALLCGTLPFDDEH--VPTLFR---- 236
            .|   ||.      |..|            ||||.|:||..|.|...|:...|  ....|:
Yeast   230 RI---LYCLNTTTNGIHVDECCSSLPTDTGDIWSLGIILINLTCIRNPWLKAHQKEDNTFQHFAN 291

  Fly   237 --KIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIE----EIKKHEWFQKDLPAYLFP 290
              .:...|.||.:    ::..::.::||::|..|.:::    |:.....|.::.|....|
Yeast   292 DNNVLKKILPISD----ELFTVLTKILQLNPYTRIDMKTLMSEVSSLTSFTREGPLSQVP 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	74/243 (30%)
		UBA_AID_AMPKalpha	297..360	CDD:270521
		AMPKA_C	457..580	CDD:213378
SKS1	NP_015299.1	PKc_like	9..331	CDD:419665	73/237 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345335
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930