Protein Alignment AMPKalpha and FRK1

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_015184.1
• Gene: FRK1 / 855962
• SGDID: S000006062
• Length: 865
• Species: Saccharomyces cerevisiae
• Alignment Length: 595
• Identity: 178/595 - (29%)
• Similarity: 275/595 - (46%)
• Gaps: 108/595 - (18%)

  Fly    23 VKIGHYLLGATLGTGTFGKVKIG-------EHQIT---RVKVAVKILNRQKIKS---LDVVGKIR 74
            |..|.|:||:|||.|.|||||:|       ....|   ..:||:|::.|..|.:   .:|  ||.
Yeast    36 VTFGPYILGSTLGEGEFGKVKLGWPKNFSNSSNSTFDFPKQVAIKLIKRDSISNDYRKEV--KIY 98

  Fly    75 REIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGV 139
            |||..||...||:|:||.:|:.....|.:::||..|||.:.||.|..:|:|..|.|.|.|:||||
Yeast    99 REINALKHLSHPNIVKLEEVLQNSRYIGIVLEYACGGEFYKYIQKKRRLKEMNACRLFSQLISGV 163

  Fly   140 DYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLD-GEFLRTSCGSPNYAAPE-VISGKLY 202
            .|.|...:||||||.||||||.|.::.|.|||..|.... .|.::||||||.||||| |||.:.|
Yeast   164 HYIHSKGLVHRDLKLENLLLDKNENLVITDFGFVNEFCSRNELMKTSCGSPCYAAPELVISAEPY 228

  Fly   203 AGPEVDIWSCGVILYALLCGTLPFDDE-------HVPTLFRKIKSGIFPIPEYLNKQVVNLVCQM 260
            ...:.|||||||||||:|.|.||:||:       .:..|:..|.|.....|:|:.....:|:.:|
Yeast   229 EARKADIWSCGVILYAILAGYLPWDDDPNNPEGSDIGRLYNYINSTPLKFPDYILPIPRDLLRRM 293

  Fly   261 LQVDPLKRANIEEIKKHEWFQKDLPAYL--FPSSIEQDSNVIDTYAVAEVCTKFGVK-ETEVHNS 322
            |..||.||.|:::||||||. |...::|  .|...::.:|....:.:|:...::|.: ::....|
Yeast   294 LVSDPKKRINLKQIKKHEWL-KPHSSFLSITPDEWDKLNNTQSVFRLAKPRRRYGSRPQSSCSTS 357

  Fly   323 LLS--GDPHDQLAI--------------AYHLIIDNKRFA-DDAANQINEINNFFVAGSPPPPPP 370
            .|.  .|..|.|.|              ..|:|......| |...:.|...|....:.|......
Yeast   358 SLGSRSDKRDSLVIDSTLITFPAPPQESQNHIITRPASIASDQRLSPIRRSNRHNRSNSAASVAL 422

  Fly   371 PPVPQSS----MDHQAPLATV-----TVGGGTSASSGTATPVPPVA-GGTPSSTIPIRPHP---E 422
            ..|..:.    :.|:..|:.|     |.|..|::.|    |.|.:: |.....|.||:.:.   .
Yeast   423 QAVVNADREYVLSHEQSLSPVQNIRQTTGNMTASLS----PPPAISPGDIIIETTPIKRNTISGS 483

  Fly   423 RIAPMRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQSKPNDIML---------EVY 478
            .|.|..:.:.:.::||                           |:.:||::..         :..
Yeast   484 SIVPSLEEESSTTMQT---------------------------SKIQPNNMASSQNHQYNKNKTQ 521

  Fly   479 RAMKALSYEWKIINPYHVRVRRQNVKTGK-----FSKMSLQLYQVDAKSYLLDFKSLTNDEVEQG 538
            .::::....::..:..|.:.|..:...|.     ::..:|.:|:::.|:.    .|.::..:.|.
Yeast   522 NSLQSAKNFYRTSSSSHTKPRPTSYHPGSYTTPPYNSNTLSIYEINEKAK----SSASSQTLNQR 582

  Fly   539 DDVIMESLTP 548
            |....:| ||
Yeast   583 DTSPFDS-TP 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	124/276 (45%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	15/80 (19%)
		AMPKA_C	457..580	CDD:213378	15/106 (14%)
FRK1	NP_015184.1	PKc_like	39..313	CDD:419665	124/275 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345340
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000976
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840