Protein Alignment AMPKalpha and HRK1

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_014910.1
• Gene: HRK1 / 854441
• SGDID: S000005793
• Length: 759
• Species: Saccharomyces cerevisiae
• Alignment Length: 274
• Identity: 74/274 - (27%)
• Similarity: 109/274 - (39%)
• Gaps: 53/274 - (19%)

  Fly    30 LGATLGTGTFGKVKIGEHQITRVKVAVKILNRQK----IKSLDVVGKIRREIQNLKLFRHPHIIK 90
            ||..||:|..|.||:..........|||....:|    :|  :...|...|........||::|:
Yeast   217 LGKLLGSGAGGSVKVLVRPTDGATFAVKEFRPRKPNESVK--EYAKKCTAEFCIGSTLHHPNVIE 279

  Fly    91 LYQVI--STPSDIFMIMEYVSGGELFDY--IVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRD 151
            ...|.  |..:..:.:|||..    .|:  :|..||:...:.....:|:..||.|.|...:.|||
Yeast   280 TVDVFSDSKQNKYYEVMEYCP----IDFFAVVMTGKMSRGEINCCLKQLTEGVKYLHSMGLAHRD 340

  Fly   152 LKPENLLLDHNMHVKIADFGLSNMML----DGEFLRTS-CGSPNYAAPEVI-SGKLYAGPEVDIW 210
            ||.:|.::.....:|:.|||.:.:..    ||..:... .||..|.||||| |.|.|....||||
Yeast   341 LKLDNCVMTSQGILKLIDFGSAVVFRYPFEDGVTMAHGIVGSDPYLAPEVITSTKSYDPQCVDIW 405

  Fly   211 SCGVILYALLCGTLPF------DDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRA 269
            |.|:|...::....|:      ||.     ||                   |.|   ..|.::..
Yeast   406 SIGIIYCCMVLKRFPWKAPRDSDDN-----FR-------------------LYC---MPDDIEHD 443

  Fly   270 NIEEIKKHEWFQKD 283
            .:|..:.||...|:
Yeast   444 YVESARHHEELLKE 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	73/269 (27%)
		UBA_AID_AMPKalpha	297..360	CDD:270521
		AMPKA_C	457..580	CDD:213378
HRK1	NP_014910.1	Protein Kinases, catalytic domain	221..435	CDD:473864	66/243 (27%)
		MSCRAMM_ClfA	<469..620	CDD:468110
		Protein Kinases, catalytic domain	<677..721	CDD:473864