Protein Alignment AMPKalpha and GIN4

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_010795.3
• Gene: GIN4 / 852119
• SGDID: S000002915
• Length: 1142
• Species: Saccharomyces cerevisiae
• Alignment Length: 548
• Identity: 177/548 - (32%)
• Similarity: 266/548 - (48%)
• Gaps: 100/548 - (18%)

  Fly    16 SANGQPLVK---IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKIL-----NRQKIKSLDVVGK 72
            :.|..|.:|   ||.:.||.|||.|:.|||::..:..|..:.|||::     |...:....:||.
Yeast     4 NGNSIPAIKDNTIGPWKLGETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGS 68

  Fly    73 ---------IRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQA 128
                     |.|||..:||..||::::||.|..|.:|:::::||...||||:.:|:.|.|.||:|
Yeast    69 TTPDALPYGIEREIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEA 133

  Fly   129 RRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAA 193
            .|||:|||.||.|||...|||||||||||||||..::||||||::.:..:|:.|.||||||:|||
Yeast   134 IRFFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYNIKIADFGMAALETEGKLLETSCGSPHYAA 198

  Fly   194 PEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDE--HVPTLFRKIKSGIFPIP--EYLNKQVV 254
            ||::||..|.|...|:|||||||:|||.|.||||:|  ::.||..|::.|.|.:|  :.::::..
Yeast   199 PEIVSGIPYQGFASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEMPSDDEISREAQ 263

  Fly   255 NLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAYLFPSSIEQDSNVI------DTYAVAEVCTKFG 313
            :|:.::|.|||.:|....:|.||...||      :||.  :||..|      |||......:...
Yeast   264 DLIRKILTVDPERRIKTRDILKHPLLQK------YPSI--RDSKSIRGLPREDTYLTPLSESNSS 320

  Fly   314 VKETEVHNSLLSGDPHDQLAI--------------AYHLIIDNKRFADDA------ANQINEINN 358
            :..|.:.|.::.....|...|              .|.|:.   ||..|.      ..|:.:..:
Yeast   321 IDATILQNLVILWHGRDPEGIKEKLREPGANAEKTLYALLY---RFKCDTQKELIKQQQVKKRQS 382

  Fly   359 FFVAGSPPPPPPPPVPQSSMDHQAPLATVTVG----------GGTSASSGTATPVPPVAGGTPSS 413
            .......|.......||...:.:: |.:||..          ..:||||...|        ||.|
Yeast   383 ISSVSVSPSKKVSTTPQRRRNRES-LISVTSSRKKPISFNKFTASSASSSNLT--------TPGS 438

  Fly   414 TIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTPI------KRAKWHLGIRSQSKPND 472
            :       :|::.....:..:|...:.....|....:..:.|      |||    .|.|.:|.|.
Yeast   439 S-------KRLSKNFSSKKKLSTIVNQSSPTPASRNKRASVINVEKNQKRA----SIFSTTKKNK 492

  Fly   473 ------IMLEVYRAMKALSYEWKIINPY 494
                  ..:.:..:||..|...|:::.|
Yeast   493 RSSRSIKRMSLIPSMKRESVTTKLMSTY 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	124/272 (46%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	15/88 (17%)
		AMPKA_C	457..580	CDD:213378	11/44 (25%)
GIN4	NP_010795.3	Protein Kinases, catalytic domain	17..289	CDD:473864	123/271 (45%)
		Kcc4p_like_C	1026..1139	CDD:213379