Protein Alignment AMPKalpha and SNF1

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_010765.3
• Gene: SNF1 / 852088
• SGDID: S000002885
• Length: 633
• Species: Saccharomyces cerevisiae
• Alignment Length: 631
• Identity: 240/631 - (38%)
• Similarity: 345/631 - (54%)
• Gaps: 129/631 - (20%)

  Fly    25 IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHII 89
            ||:|.:..|||.|:|||||:..|..|..|||:||:|::.:...|:.|:|.|||..|:|.||||||
Yeast    52 IGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHII 116

  Fly    90 KLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKP 154
            |||.||.:..:|.|::|| :|.|||||||:..|:.|.:||||||||||.|:|||||.||||||||
Yeast   117 KLYDVIKSKDEIIMVIEY-AGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKIVHRDLKP 180

  Fly   155 ENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYAL 219
            ||||||.:::||||||||||:|.||.||:|||||||||||||||||||||||||:||||||||.:
Yeast   181 ENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVM 245

  Fly   220 LCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDL 284
            ||..||||||.:|.||:.|.:|::.:|::|:.....|:.:||.|:||.|.:|.||.:.:||:.||
Yeast   246 LCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVDL 310

  Fly   285 PAYLFPSSIE------------------QDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGD---P 328
            |.||.|..::                  .|::.||...|..:.:..|.::.|::.||.|.:   .
Yeast   311 PEYLLPPDLKPHPEEENENNDSKKDGSSPDNDEIDDNLVNILSSTMGYEKDEIYESLESSEDTPA 375

  Fly   329 HDQLAIAYHLIIDNKRFADD--AANQINEINNFFVAGSPPP-----------------------P 368
            .:::..||.||.:||....|  |...:::..:.|::.|||.                       .
Yeast   376 FNEIRDAYMLIKENKSLIKDMKANKSVSDELDTFLSQSPPTFQQQSKSHQKSQVDHETAKQHARR 440

  Fly   369 PPPPVPQSSMDHQAPL--------ATVTVGGGTSASSGTATPVPPV------AGGTPSSTIPIRP 419
            ....:.|....||:|.        :||::         ..|.:|.:      |.|:|:::
Yeast   441 MASAITQQRTYHQSPFMDQYKEEDSTVSI---------LPTSLPQIHRANMLAQGSPAAS----- 491

  Fly   420 HPERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQSKPNDIMLEVYRAMKAL 484
               :|:|:..::                        .:.:||.||||:|.|.|:|.|:|.|:|.|
Yeast   492 ---KISPLVTKK------------------------SKTRWHFGIRSRSYPLDVMGEIYIALKNL 529

  Fly   485 SYEWKIINP-----YHVRVR---------RQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTNDEV 535
            ..||  ..|     :.:::|         ..|.|.....||.:||:|::..:||:||| ....|.
Yeast   530 GAEW--AKPSEEDLWTIKLRWKYDIGNKTNTNEKIPDLMKMVIQLFQIETNNYLVDFK-FDGWES 591

  Fly   536 EQGDDVIMESLTPPPLSVSGVMPLQPTGHHTMEFFEMCAALIIQLA 581
            ..|||..:.:::...:|.....|          |..:...||::||
Yeast   592 SYGDDTTVSNISEDEMSTFSAYP----------FLHLTTKLIMELA 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	156/254 (61%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	16/67 (24%)
		AMPKA_C	457..580	CDD:213378	40/136 (29%)
SNF1	NP_010765.3	STKc_AMPK_alpha	52..306	CDD:270981	156/254 (61%)
		UBA_2	344..389	CDD:400760	12/44 (27%)
		AdenylateSensor	504..626	CDD:406881	40/134 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	329	1.000	Domainoid score	I172
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4551
Inparanoid	1	1.050	406	1.000	Inparanoid score	I307
Isobase	1	0.950	-	0	Normalized mean entropy	S655
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000976
OrthoInspector	1	1.000	-	-		oto99989
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1362
SonicParanoid	1	1.000	-	-		X997
TreeFam	1	0.960	-	-
	12	12.000