DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPKalpha and KIN1

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_010407.1	Gene:	KIN1 / 851700	SGDID:	S000002529	Length:	1064	Species:	Saccharomyces cerevisiae

Alignment Length:	721	Identity:	194/721 - (26%)
Similarity:	304/721 - (42%)	Gaps:	194/721 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SANGQP----LVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNR------QKIKSL--- 67
            |:.|.|    ...:|.:....|:|.|:.||||:.:|:.|....||||:||      .|.:.|
Yeast   104 SSQGMPKQFHRKSLGDWEFVETVGAGSMGKVKLAKHRYTNEVCAVKIVNRATKAFLHKEQMLPPP 168

  Fly    68 ----DVV---GKIRREIQNLK----------LFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFD 115
                ||:   .|:.:||...|          :..||||.:|:::.:..:..:|:.||||||:|.|
Yeast   169 KNEQDVLERQKKLEKEISRDKRTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLD 233

  Fly   116 YIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGE 180
            ||::||.::|||||:|.:.|.|.:.|.|.:.|||||||.||:::..:..:||.||||||:....:
Yeast   234 YIIQHGSIREHQARKFARGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRK 298

  Fly   181 FLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPI 245
            .|.|.|||..:||||::....|.|||||:||.||:|:.|:||.:|||||:...|..|||.|....
Yeast   299 QLHTFCGSLYFAAPELLKANPYTGPEVDVWSFGVVLFVLVCGKVPFDDENSSVLHEKIKQGKVEY 363

  Fly   246 PEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEW----FQKDLPAYL---FPSSIEQ-DSNVI-- 300
            |::|:.:|::|:.:||.|||.:||.::::.:|.|    |....|:||   .|.:||. |.||:
Yeast   364 PQHLSIEVISLLSKMLVVDPKRRATLKQVVEHHWMVRGFNGPPPSYLPKRVPLTIEMLDINVLKE 428

  Fly   301 -----------------------DTYAVAE-----VCTKFGVKETEVHNSLLSGDPHDQLAIAYH 337
                                   .||.:..     :..|...:.::..|:....:..:....|||
Yeast   429 MYRLEFIDDVEETRSVLVSIITDPTYVLLSRQYWTLAAKMNAESSDNGNAPNITESFEDPTRAYH 493

  Fly   338 LII----------DNK---------RFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAP 383
            .:|          |.|         |.:.:...:::||                 |:|.......
Yeast   494 PMISIYYLTSEMLDRKHAKIRNQQQRQSHENIEKLSEI-----------------PESVKQRDVE 541

  Fly   384 LATVTVGG---GTSASSGTATP-VPPVAGGT---------PSSTIPIRPHPERIA------PMRD 429
            :.|..:..   .|.|:..|:.| .|..:.||         |...:|.:.|....:      ..|:
Yeast   542 VNTTAMKSEPEATLATKDTSVPFTPKNSDGTEPPLHVLIPPRLAMPEQAHTSPTSRKSSDNQRRE 606

  Fly   430 RQLAMSVQTSGGG----AFPEKTARGGTPIKRAKWHLGIR--SQSKPNDIMLEVYRAMKALSYEW 488
            .:.|:|....|..    ..|..|   |.|.::||:....|  ||.:...|......:..:::
Yeast   607 MEYALSPTPQGNDYQQFRVPSTT---GDPSEKAKFGNIFRKLSQRRKKTIEQTSVNSNNSIN--- 665

  Fly   489 KIINPYHVR------------------VRRQNVKT--------GKFSKMSLQL---------YQV 518
            |.:...|.|                  ...:.|||        |.|..:....         .|:
Yeast   666 KPVQKTHSRAVSDFVPGFAKPSYDSNYTMNEPVKTNDSRGGNKGDFPALPADAENMVEKQREKQI 730

  Fly   519 DAKSYLLDFKSLTNDEVEQG---------------DDVIMESLTPPPLSVSGVMPLQPT------ 562
            :.....|...:..|:||.:|               ||   |:...|||:|:....|.|:
Yeast   731 EEDIMKLHDINKQNNEVAKGSGREAYAAQKFEGSDDD---ENHPLPPLNVAKGRKLHPSARAKSV 792

  Fly   563 GHHTME 568
            ||...|
Yeast   793 GHARRE 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	115/284 (40%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	15/111 (14%)
		AMPKA_C	457..580	CDD:213378	32/170 (19%)
KIN1	NP_010407.1	STKc_Kin1_2	118..398	CDD:270979	114/279 (41%)
KIN1	NP_010407.1	MARK_C_like	890..1062	CDD:213377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345337
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840