Protein Alignment AMPKalpha and KIN2

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_013197.1
• Gene: KIN2 / 850785
• SGDID: S000004086
• Length: 1147
• Species: Saccharomyces cerevisiae
• Alignment Length: 724
• Identity: 183/724 - (25%)
• Similarity: 297/724 - (41%)
• Gaps: 220/724 - (30%)

  Fly    25 IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNR----------------------QKIKSL 67
            :|.:....|:|.|:.||||:.:|:.|:....:||:||                      ::.|.|
Yeast    96 LGDWEFLETVGAGSMGKVKLVKHRQTKEICVIKIVNRASKAYLHKQHSLPSPKNESEILERQKRL 160

  Fly    68 D-VVGKIRREIQNLKL---FRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQA 128
            : .:.:.:|.::...|   ..||||.:|:::.:..:..:|:.||||||:|.|||::||.|:||.|
Yeast   161 EKEIARDKRTVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHA 225

  Fly   129 RRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAA 193
            |:|.:.|.|.:.|.|.:.|||||||.||:::..:..:||.||||||:....:.|.|.|||..:||
Yeast   226 RKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQLHTFCGSLYFAA 290

  Fly   194 PEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVC 258
            ||::..:.|.||||||||.|::||.|:||.:|||||:...|..|||.|....|.:|:.:|::|:.
Yeast   291 PELLKAQPYTGPEVDIWSFGIVLYVLVCGKVPFDDENSSILHEKIKKGKVDYPSHLSIEVISLLT 355

  Fly   259 QMLQVDPLKRANIEEIKKHEWFQK----DLPAYLFPSSIEQDSNVIDTYAVAE------------ 307
            :|:.||||:||.::.:.:|.|..:    ..|:|: |:.:.....:||:..:.|
Yeast   356 RMIVVDPLRRATLKNVVEHPWMNRGYDFKAPSYV-PNRVPLTPEMIDSQVLKEMYRLEFIDDIED 419

  Fly   308 --------VCTKFGV-----------------------------KETEVHNSLLSG--------- 326
                    |..|..:                             ::|.:.|.:.|.
Yeast   420 TRRSLIRLVTEKEYIQLSQEYWDKLSNAKGLSSSLNNNYLNSTAQQTLIQNHITSNPSQSGYNEP 484

  Fly   327 -----DP----HDQLAIAYHLIID-----------NKRFADDAANQINE------------INNF 359
                 ||    |..|:| |||:.:           .:..|..|..|..:            :||
Yeast   485 DSNFEDPTLAYHPLLSI-YHLVSEMVARKLAKLQRRQALALQAQAQQRQQQQQVALGTKVALNN- 547

  Fly   360 FVAGSPP------PPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGTPSSTIPIR 418
               .||.      .|....||...:.....:.|    .|||.::.|:...|......|..|||.:
Yeast   548 ---NSPDIMTKMRSPQKEVVPNPGIFQVPAIGT----SGTSNNTNTSNKPPLHVMVPPKLTIPEQ 605

  Fly   419 PHPERIAPMRDRQLAMSVQTSG---------GGAFPEKTARGGTPIKRAKWHLG----------- 463
            .|   .:|...:...:..:.:|         .|.:.:::|.......:.|..:|
Yeast   606 AH---TSPTSRKSSDIHTELNGVLKSTPVPVSGEYQQRSASPVVGEHQEKNTIGGIFRRISQSGQ 667

  Fly   464 ----IRSQ------------SKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMS 512
                .|.|            ||.|:|.::|.::..      :.|:.|....||.    ..:...|
Yeast   668 SQHPTRQQEPLPEREPPTYMSKSNEISIKVPKSHS------RTISDYIPSARRY----PSYVPNS 722

  Fly   513 LQLYQVDAKSYLLDFKSLTNDEVEQGDDVIMESLTPPPLSVS----GVMPLQPTGHHTMEFFEMC 573
            :.:.|..||:                     .::.||..|||    ..:|..|..
Yeast   723 VDVKQKPAKN---------------------TTIAPPIRSVSQKQNSDLPALPQN---------- 756

  Fly   574 AALIIQLAR 582
            |.||:|..|
Yeast   757 AELIVQKQR 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	109/280 (39%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	21/152 (14%)
		AMPKA_C	457..580	CDD:213378	27/153 (18%)
KIN2	NP_013197.1	STKc_Kin1_2	97..377	CDD:270979	109/279 (39%)
		KA1	1104..1147	CDD:396635

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345336
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840