Protein Alignment AMPKalpha and KCC4

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_009907.2
• Gene: KCC4 / 850334
• SGDID: S000000529
• Length: 1037
• Species: Saccharomyces cerevisiae
• Alignment Length: 620
• Identity: 187/620 - (30%)
• Similarity: 282/620 - (45%)
• Gaps: 129/620 - (20%)

  Fly     4 MRAAAAEAVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSL- 67
            |..|..|..:|    .:|...||.:.||.|||.|:.|||::.:|:.|..:.|||:::    ||:
Yeast     1 MTVANTETHSA----AKPSSTIGPWKLGETLGFGSTGKVQLAQHERTGHRTAVKVIS----KSIF 57

  Fly    68 ---------DVV--GKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHG 121
                     |.|  ..|.|||..:||..||:::.||.|..|.:::::|:||...||||:.:|.||
Yeast    58 NNNGNHSNDDSVLPYNIEREIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHG 122

  Fly   122 KLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSC 186
            .|.|.:|...|:|||.|:.|||...||||||||||||||...::||||||::.:..|.:.|.|||
Yeast   123 PLPEREAINCFRQIIIGISYCHALGIVHRDLKPENLLLDSFYNIKIADFGMAALQTDADLLETSC 187

  Fly   187 GSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDE--HVPTLFRKIKSGIFPIPE-- 247
            |||:|||||::||..|.|...|:|||||||:|||.|.||||:|  :|..|..|::.|.|.:|.
Yeast   188 GSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDT 252

  Fly   248 YLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQ-----------KDLP---AYLFP-------S 291
            .:::...:|:.::|.|||.:|..|.:|..|...:           ||||   .||:|       :
Yeast   253 EISRDAQDLIGKILVVDPRQRIKIRDILSHPLLKKYQTIKDSKSIKDLPRENTYLYPLADSNNHT 317

  Fly   292 SIEQDSNVIDTYAVA-------EVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIID-------- 341
            |...|.:::....|.       ::.:|.....|.....|        .|:.|...:|
Yeast   318 SASIDDSILQNLVVLWHGRHADDIVSKLKENGTNKEKIL--------YALLYRFKLDSVRGSNKK 374

  Fly   342 ----------NKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSAS 396
                      |||.:..:::....:||..:..:|.       .::|..|....::     ....|
Yeast   375 NRNKIKKTKKNKRSSTLSSSSSLLLNNRSIQSTPR-------RRTSKRHSREFSS-----SRKRS 427

  Fly   397 SGTATPVPPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWH 461
            |...:..|     |.||.||:| ..:||..:.... |.:..|..|...|.|.    ...||:...
Yeast   428 SFLLSSNP-----TDSSPIPLR-SSKRITHINVAS-ANTQATPSGVPNPHKR----NSKKRSSKR 481

  Fly   462 LGIRSQSKPNDIMLEVYRAMKALSY--------EWKIINPYHVRV------------RRQNVKTG 506
            |.....:|.:.:      ..|:||.        :|:.|.....|.            ..:..:..
Yeast   482 LSYMPNTKRSSL------TSKSLSNFTNLIDDDDWEYIEKDAKRTSSNFATLIDEIFEPEKFELA 540

  Fly   507 KFSKMSLQLYQVDAKSYLLDFKSLTNDEVEQGDDV 541
            |..|..||....:||...::.:.:..||.  |.:|
Yeast   541 KREKAELQRKVQEAKRQSVNAQKINEDEF--GSEV 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	122/270 (45%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	12/87 (14%)
		AMPKA_C	457..580	CDD:213378	19/105 (18%)
KCC4	NP_009907.2	PKc_like	19..285	CDD:419665	121/269 (45%)
		Kcc4p_like_C	920..1034	CDD:213379

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910