Protein Alignment AMPKalpha and BRSK1

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_115806.1
• Gene: BRSK1 / 84446
• HGNCID: 18994
• Length: 778
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 181/521 - (34%)
• Similarity: 264/521 - (50%)
• Gaps: 124/521 - (23%)

  Fly    25 IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHII 89
            :|.|.|..|||.|..|.||:|.|.||..|||:||:||:|: |..|:.|:.|||..|||..|||::
Human    31 VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPHVL 94

  Fly    90 KLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKP 154
            ||:.|......:::::|:|||||||||:||.|:|...:||:||:||:|.:|:||.:.|.||||||
Human    95 KLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKP 159

  Fly   155 ENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYAL 219
            ||||||...:::|||||::::.:....|.||||||:||.||||.|:.|.|...|:|||||||:||
Human   160 ENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFAL 224

  Fly   220 LCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWF---- 280
            |.|.|||||:::..|..|:|.|:|.:|.::.....:|:..|::|:|.||.::|:|:||.|:
Human   225 LVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGK 289

  Fly   281 -----------QKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAI 334
                       .:.:.....||:.|.|.:|:::.| :..|  |..:| .:|..|.| :..:|..:
Human   290 HEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMA-SLGC--FRDRE-RLHRELRS-EEENQEKM 349

  Fly   335 AYHLIIDNKRFADDAANQINEINNFFVAGSPP----PPPPPPVPQSSMDHQAP----------LA 385
            .|:|::|.|.......:|          ..||    .||...|....:.....          |:
Human   350 IYYLLLDRKERYPSCEDQ----------DLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLS 404

  Fly   386 TVTVGGGTS---------------------------ASSGTATPVPPV--------------AGG 409
            ....|||.|                           :||..::|..||              .||
Human   405 ITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGG 469

  Fly   410 TPSS---TIPIRPHPERIAPMRDRQLAMSVQTSGGGAF---PEKTAR--------------GGTP 454
            :|:|   |:|.|      .|            .||||.   |..:||              ||||
Human   470 SPTSKTQTLPSR------GP------------RGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTP 516

  Fly   455 I 455
            :
Human   517 L 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	128/254 (50%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	14/62 (23%)
		AMPKA_C	457..580	CDD:213378
BRSK1	NP_115806.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		STKc_BRSK1_2	32..285	CDD:270983	128/253 (51%)
		UBA_BRSK	314..367	CDD:270525	15/57 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..548		35/184 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	719..778

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910