DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPKalpha and CIPK21

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_568860.1	Gene:	CIPK21 / 835868	AraportID:	AT5G57630	Length:	416	Species:	Arabidopsis thaliana

Alignment Length:	327	Identity:	125/327 - (38%)
Similarity:	185/327 - (56%)	Gaps:	36/327 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHI 88
            |||.|.:|.|:|.|.|.|||:|........|||||:::..:....:..:::|||:.:||..||:|
plant     8 KIGKYEIGRTIGEGNFAKVKLGYDTTNGTYVAVKIIDKALVIQKGLESQVKREIRTMKLLNHPNI 72

  Fly    89 IKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLK 153
            :::::||.|.:.|.::|||||||:|.|.:.:. |::|..||:.|||:|..|||||...:.|||||
plant    73 VQIHEVIGTKTKICIVMEYVSGGQLSDRLGRQ-KMKESDARKLFQQLIDAVDYCHNRGVYHRDLK 136

  Fly   154 PENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYA 218
            |:|||||...::|::|||||.:...|:.|.|:||||.|.|||:|..|.|:|..||:|||||||:.
plant   137 PQNLLLDSKGNLKVSDFGLSAVPKSGDMLSTACGSPCYIAPELIMNKGYSGAAVDVWSCGVILFE 201

  Fly   219 LLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEE-IKKHEWFQ- 281
            ||.|..||||..:|.|::||....:..|.....:...|:..:|..:||.|..:.| |.|..||:
plant   202 LLAGYPPFDDHTLPVLYKKILRADYTFPPGFTGEQKRLIFNILDPNPLSRITLAEIIIKDSWFKI 266

  Fly   282 -------------KDLPAYLFPSSIEQDSNVIDTYAVAEVC------------------TKFGVK 315
                         ||..|.:  ::....||.|:.:.:..:.                  |:.|.|
plant   267 GYTPVYHQLSDSIKDNVAEI--NAATASSNFINAFQIIAMSSDLDLSGLFEENDDKRYKTRIGSK 329

  Fly   316 ET 317
            .|
plant   330 NT 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	112/255 (44%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	7/39 (18%)
		AMPKA_C	457..580	CDD:213378
CIPK21	NP_568860.1	PKc_like	11..263	CDD:419665	110/252 (44%)
CIPK21	NP_568860.1	CIPK_C	297..411	CDD:213380	4/35 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000976
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910