DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPKalpha and SnRK1.3

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_198760.1	Gene:	SnRK1.3 / 833940	AraportID:	AT5G39440	Length:	494	Species:	Arabidopsis thaliana

Alignment Length:	577	Identity:	230/577 - (39%)
Similarity:	321/577 - (55%)	Gaps:	126/577 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 HYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKL 91
            :|.:|.|||.|:|.|||:..|..|..|||:|||||.|||::.:..|::|||:.|:...|||||:.
plant    18 NYRIGKTLGHGSFAKVKLALHVATGHKVAIKILNRSKIKNMGIEIKVQREIKILRFLMHPHIIRQ 82

  Fly    92 YQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPEN 156
            |:||.||:||:::||||..||||||||:.|||||.:||..||||||||:||||:|||||||||||
plant    83 YEVIETPNDIYVVMEYVKSGELFDYIVEKGKLQEDEARHLFQQIISGVEYCHRNMIVHRDLKPEN 147

  Fly   157 LLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLC 221
            :|||...::||.||||||:|.||.||:|||||||||||||||||.| ||:|||||||||||||||
plant   148 VLLDSQCNIKIVDFGLSNVMHDGHFLKTSCGSPNYAAPEVISGKPY-GPDVDIWSCGVILYALLC 211

  Fly   222 GTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPA 286
            ||||||||::|.:|.|||.|::.:|.:|:....:|:.:||.|||..|.:|.||::|.||...||.
plant   212 GTLPFDDENIPNVFEKIKRGMYTLPNHLSHFARDLIPRMLMVDPTMRISITEIRQHPWFNNHLPL 276

  Fly   287 YL-FP--SSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADD 348
            || .|  .:|:|...:.:  .:.:.....|.....|.:| |:....::..:|||||:||:
plant   277 YLSIPPLDTIDQAKKIEE--EIIQNVVNIGFDRNHVVDS-LANRIQNEATVAYHLILDNR----- 333

  Fly   349 AANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGTPSS 413
              ||.:..|:.|              ||....                         ::.|..:|
plant   334 --NQNSVPNDPF--------------QSKFKE-------------------------ISDGIFNS 357

  Fly   414 TIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARGG--TPIKRAK-WHLGIRSQSKPNDIML 475
            |:|::                ::.:..|.:|   :|..|  :.:|..| |.||::||..|.|||.
plant   358 TLPVQ----------------NITSHVGHSF---SALYGLKSNVKDDKTWTLGLQSQGSPYDIMT 403

  Fly   476 EVYRAMKALSYEWKIINPYHVRVRRQNVKTGKF-----------------SKMSLQLYQVDAKSY 523
            |:::|::.|...||.|..|:::.|.  |::..:                 .|..:|||:|....|
plant   404 EIFKALQNLKICWKKIGLYNIKCRW--VRSFAYYKNHTIEDECAIILPTVIKFEIQLYKVREGKY 466

  Fly   524 LLDFKSLTNDEVEQGDDVIMESLTPPPLSVSGVMPLQPTGHHTMEFFEMCAALIIQL 580
            |||.                       |.:.|...:         ||::|.|.:.:|
plant   467 LLDI-----------------------LRIDGPQFI---------FFDLCVAFLREL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	160/252 (63%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	14/62 (23%)
		AMPKA_C	457..580	CDD:213378	34/140 (24%)
SnRK1.3	NP_198760.1	STKc_AMPK_alpha	16..270	CDD:270981	160/252 (63%)
		UBA_SnRK1_plant	292..332	CDD:270520	9/42 (21%)
		AMPKA_C	388..491	CDD:213378	33/136 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	376	1.000	Domainoid score	I169
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	418	1.000	Inparanoid score	I441
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000976
OrthoInspector	1	1.000	-	-		otm3018
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X997
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	9.020