DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPKalpha and SNRK2.2

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001190047.1	Gene:	SNRK2.2 / 824214	AraportID:	AT3G50500	Length:	369	Species:	Arabidopsis thaliana

Alignment Length:	318	Identity:	118/318 - (37%)
Similarity:	172/318 - (54%)	Gaps:	37/318 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ANGQPLVKI--------GHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNR-QKIKSLDVVGK 72
            |...|::.|        ..|.....:|:|.||..::...::|:..||||.:.| :||..     .
plant     4 ATNSPIMPIDLPIMHDSDRYDFVKDIGSGNFGVARLMTDRVTKELVAVKYIERGEKIDE-----N 63

  Fly    73 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIIS 137
            ::|||.|.:..|||:|::..:||.|||.:.::|||.:||||::.|...|:..|.:||.||||:||
plant    64 VQREIINHRSLRHPNIVRFKEVILTPSHLAIVMEYAAGGELYERICNAGRFSEDEARFFFQQLIS 128

  Fly   138 GVDYCHRHMIVHRDLKPENLLLDHN--MHVKIADFGLSNMM---LDGEFL----RTSCGSPNYAA 193
            ||.|||...|.|||||.||.|||.:  ..:||.|||.|.::   |....|    :::.|:|.|.|
plant   129 GVSYCHAMQICHRDLKLENTLLDGSPAPRLKICDFGYSKVLFISLKSSVLHSQPKSTVGTPAYIA 193

  Fly   194 PEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRK----IKSGIFPIPE--YLNKQ 252
            ||::..:.|.|...|:|||||.||.:|.|..||:|...|..:||    |.|..:.|||  :|:.:
plant   194 PEILLRQEYDGKLADVWSCGVTLYVMLVGAYPFEDPQEPRDYRKTIQRILSVTYSIPEDLHLSPE 258

  Fly   253 VVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAYLFPSS--------IEQDSNVIDT 302
            ..:|:.::...||..|..|.||...:||.|:||..|...:        .||....:||
plant   259 CRHLISRIFVADPATRITIPEITSDKWFLKNLPGDLMDENRMGSQFQEPEQPMQSLDT 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	106/278 (38%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	2/6 (33%)
		AMPKA_C	457..580	CDD:213378
SNRK2.2	NP_001190047.1	PKc_like	22..285	CDD:304357	105/267 (39%)
SNRK2.2	NP_001190047.1	S_TKc	23..286	CDD:214567	105/267 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010