DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPKalpha and KIN11

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_566843.1	Gene:	KIN11 / 822566	AraportID:	AT3G29160	Length:	512	Species:	Arabidopsis thaliana

Alignment Length:	586	Identity:	252/586 - (43%)
Similarity:	330/586 - (56%)	Gaps:	127/586 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 HYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKL 91
            :|.||.|||.|:||||||.||.:|..|||:|||||:|||::::..|:||||:.|:||.|||||:.
plant    19 NYKLGKTLGIGSFGKVKIAEHVVTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPHIIRQ 83

  Fly    92 YQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPEN 156
            |:||.|.|||:::||||..||||||||:.|:|||.:||.|||||||||:||||:|:|||||||||
plant    84 YEVIETTSDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPEN 148

  Fly   157 LLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLC 221
            ||||...::|||||||||:|.||.||:|||||||||||||||||||||||||:||||||||||||
plant   149 LLLDSRCNIKIADFGLSNVMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLC 213

  Fly   222 GTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPA 286
            ||||||||::|.||:|||.||:.:|.:|:.:..:|:.:||.|||:||..|.||::|.|||..||.
plant   214 GTLPFDDENIPNLFKKIKGGIYTLPSHLSSEARDLIPRMLIVDPVKRITIPEIRQHRWFQTHLPR 278

  Fly   287 YLF---PSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADD 348
            ||.   |.::|| :..|:...|.|| ...|....:|..||.:...:| ..:.|:|::|| ||.
plant   279 YLAVSPPDTVEQ-AKKINEEIVQEV-VNMGFDRNQVLESLRNRTQND-ATVTYYLLLDN-RFR-- 337

  Fly   349 AANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGTP-S 412
                                    ||...::.:....|         .||:.....|.||.:| .
plant   338 ------------------------VPSGYLESEFQETT---------DSGSNPMRTPEAGASPVG 369

  Fly   413 STIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQSKPNDIMLEV 477
            ..||..                 |...|.|      ||...|:.| ||.||::|.:.|.:||.||
plant   370 HWIPAH-----------------VDHYGLG------ARSQVPVDR-KWALGLQSHAHPREIMNEV 410

  Fly   478 YRAMKALSYEWKIINPYHVRVR-------RQNVKTGK---------------------FSKMSLQ 514
            .:|::.|:..||.|..|:::.|       .||.....                     ..|..||
plant   411 LKALQELNVCWKKIGHYNMKCRWVPGLADGQNTMVNNQLHFRDESSIIEDDCAMTSPTVIKFELQ 475

  Fly   515 LYQVDAKSYLLDFKSLTNDEVEQGDDVIMESLTPPPLSVSGVMPLQPTGHHTMEFFEMCAALIIQ 579
            ||:...:.||||.:                       .|:|...|         |.::|||.:.:
plant   476 LYKAREEKYLLDIQ-----------------------RVNGPQFL---------FLDLCAAFLTE 508

  Fly   580 L 580
            |
plant   509 L 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	173/252 (69%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	15/62 (24%)
		AMPKA_C	457..580	CDD:213378	36/150 (24%)
KIN11	NP_566843.1	STKc_AMPK_alpha	17..272	CDD:270981	173/252 (69%)
		UBA_SnRK1_plant	294..334	CDD:270520	11/41 (27%)
		AMPKA_C	391..509	CDD:213378	36/150 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	376	1.000	Domainoid score	I169
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	418	1.000	Inparanoid score	I441
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000976
OrthoInspector	1	1.000	-	-		otm3018
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X997
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	9.020