DRSC/TRiP Functional Genomics Resources

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Protein Alignment AMPKalpha and Nuak1

DIOPT Version :9

Sequence 1:NP_477313.1 Gene:AMPKalpha / 43904 FlyBaseID:FBgn0023169 Length:582 Species:Drosophila melanogaster
Sequence 2:NP_001004363.1 Gene:Nuak1 / 77976 MGIID:1925226 Length:658 Species:Mus musculus


Alignment Length:678 Identity:205/678 - (30%)
Similarity:289/678 - (42%) Gaps:177/678 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 MRAAAAEAVAAGSA-----NGQPL------------------VKIGH--------YLLGATLGTG 37
            |..||..|...|.|     .|.||                  ||..|        |.|..|||.|
Mouse     1 MEGAAVSAAGDGPAVETGLPGSPLEAVAGATAAPVEPRKPHGVKRHHHKHNLKHRYELQETLGKG 65

  Fly    38 TFGKVKIGEHQITRVKVAVKILNRQKIK-SLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDI 101
            |:||||....:.:...||:|.:.:.||| .||:| .|||||:.:....|||||.:|:|......|
Mouse    66 TYGKVKRATERFSGRVVAIKSIRKDKIKDELDMV-HIRREIEIMSSLNHPHIISIYEVFENKDKI 129

  Fly   102 FMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVK 166
            .:||||.|.|||:|||.:..:|.|.:.|.||:||:|.|.|||::.:||||||.||:|||.|.::|
Mouse   130 VIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIK 194

  Fly   167 IADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHV 231
            ||||||||:....:||:|.||||.||:||:::|:.|.|||||.|:.||:||.|:.||:|||....
Mouse   195 IADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLIYGTMPFDGFDH 259

  Fly   232 PTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAYLFPSSI--- 293
            ..|.|:|.||.:..|.. ......|:..||.|:|.:||.||:|..|.|..     :.:.||:   
Mouse   260 KNLIRQISSGEYREPTQ-PSDARGLIRWMLMVNPDRRATIEDIANHWWVN-----WGYKSSVCDC 318

  Fly   294 ----EQDS----NVIDTY-------AVAEV-------------------CTKFGVKETEVHNSLL 324
                :.:|    .:||.:       |.||.                   ..|...||.:...|..
Mouse   319 DALPDSESPLLARIIDWHHRSTGLQAEAEAKMKGLAKPGASEVVLERQRSLKKSKKENDFPQSGQ 383

  Fly   325 SGDPHDQLAIAYHLIIDNKR----FADDAANQINEINNFFVAG--SPPPPPP------------- 370
            ...|.....::      :||    ....:.::....:..|:.|  ||..|.|             
Mouse   384 DSVPESPSKLS------SKRPKGILKKRSNSEHRSHSTGFIEGIVSPALPSPFKMEQDLCRTAIP 442

  Fly   371 -PPVPQSSMDHQAPL---ATVTVGG----------------------------GTSASSGTATPV 403
             |..|::.|..:..|   ||:...|                            ....|.|.::|.
Mouse   443 LPSSPEADMSGKLSLKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVVISGGLSSPP 507

  Fly   404 PPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFP----------EKTARGGTPIKRA 458
            |..|.||..|          ::..|...|..|.:.|.||..|          |..:..|.|..  
Mouse   508 PDPARGTSHS----------LSCRRKGILKHSSRYSDGGTDPALTRPEMPTLESLSPPGVPSD-- 560

  Fly   459 KWHLGI-RSQSKPNDIMLEVYRAMKALSYE-WKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDA- 520
                || ||.|:|:.|:.:    ...||.: :.::.....|..||.:::...::..|||...:. 
Mouse   561 ----GISRSYSRPSSIISD----DSVLSSDSFDLLELQENRPARQRIRSCVSAENFLQLQDFETP 617

  Fly   521 -----KSYL-----LDFKSLTN-DEVEQ 537
                 ..||     ..|..||: |:|.|
Mouse   618 HNRPRPQYLKRLADSSFSLLTDMDDVTQ 645

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AMPKalphaNP_477313.1 STKc_AMPK_alpha 25..280 CDD:270981 124/263 (47%)
UBA_AID_AMPKalpha 297..360 CDD:270521 13/96 (14%)
AMPKA_C 457..580 CDD:213378 23/95 (24%)
Nuak1NP_001004363.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..53 12/51 (24%)
STKc_NUAK 54..307 CDD:270975 123/254 (48%)
S_TKc 56..307 CDD:214567 123/252 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 353..422 9/74 (12%)
GILK motif 400..403 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 441..568 29/142 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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