DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and Brsk2

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001009930.1	Gene:	Brsk2 / 75770	MGIID:	1923020	Length:	719	Species:	Mus musculus

Alignment Length:	505	Identity:	176/505 - (34%)
Similarity:	264/505 - (52%)	Gaps:	93/505 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHII 89
            :|.|.|..|||.|..|.||:|.|.:|..|||:||:||:|: |..|:.|:.|||..|||..|||::
Mouse    17 VGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPHVL 80

  Fly    90 KLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKP 154
            ||:.|......:::::|:|||||||||:||.|:|...:||:||:||||.:|:||.|.|.||||||
Mouse    81 KLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKP 145

  Fly   155 ENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYAL 219
            ||||||...:::|||||::::.:....|.||||||:||.||||.|:.|.|.:.|:|||||||:||
Mouse   146 ENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFAL 210

  Fly   220 LCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWF---- 280
            |.|.|||||:::..|..|:|.|:|.:|.::.....:|:..|::||..:|..:|.|:||.|:
Mouse   211 LVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGK 275

  Fly   281 -----QKDLPAYL----FPSSIEQDSNVIDT-YAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIA 335
                 ::.:|..:    .||..:.|.:|:|: :::.  |.:   ...::...||| :..:|..:.
Mouse   276 NEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLG--CFR---DRNKLLQDLLS-EEENQEKMI 334

  Fly   336 YHLIIDNKR----FADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQA---------PLATV 387
            |.|::|.|.    ..|:.....|||:          ||...|....::...         .:.:|
Mouse   335 YFLLLDRKERYPSHEDEDLPPRNEID----------PPRKRVDSPMLNRHGKRRPERKSMEVLSV 389

  Fly   388 TVGGG--------------------TSASSGTAT-----------------PVPPVAG------- 408
            |.||.                    :.||||.:|                 |:|...|
Mouse   390 TDGGSPVPARRAIEMAQHGQRSRSISGASSGLSTSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPK 454

  Fly   409 ----GTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTP 454
                |||:.|.|..|....: |.|.|..::.....|...|..:..:..||
Mouse   455 ESPAGTPNPTPPSSPSVGGV-PWRTRLNSIKNSFLGSPRFHRRKLQVPTP 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	128/254 (50%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	15/67 (22%)
		AMPKA_C	457..580	CDD:213378
Brsk2	NP_001009930.1	STKc_BRSK1_2	18..271	CDD:270983	128/253 (51%)
Brsk2	NP_001009930.1	UBA_BRSK	298..351	CDD:270525	12/58 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910