DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPKalpha and Nuak2

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001181954.1	Gene:	Nuak2 / 74137	MGIID:	1921387	Length:	639	Species:	Mus musculus

Alignment Length:	601	Identity:	179/601 - (29%)
Similarity:	266/601 - (44%)	Gaps:	174/601 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RAAAAEAVAAGSA---------NGQPLVK------------IGH-YLLGATLGTGTFGKVKIGEH 47
            :|.:|.|:|:.||         :.:||:|            :.| |....|||.||:||||....
Mouse    12 QAPSASALASESARPLADGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKKARE 76

  Fly    48 QITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQ--------VISTPSDIFMI 104
            ...|: ||:|.:.:.|||....:..|||||:.:....|||||.:::        |....|.|.::
Mouse    77 SSGRL-VAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPHIIAIHEVGRSRLVTVFENSSKIVIV 140

  Fly   105 MEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIAD 169
            |||.|.|:|:|||.:..:|.|..||.||:||:|.:.|||::.|||||||.||:|||.|.::||||
Mouse   141 MEYASRGDLYDYISERPRLSERDARHFFRQIVSALHYCHQNGIVHRDLKLENILLDANGNIKIAD 205

  Fly   170 FGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL 234
            |||||:...|:||:|.||||.||:||:::||.|.|||||.||.||:||.|:.||:|||.:...||
Mouse   206 FGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDSWSLGVLLYILVHGTMPFDGQDHKTL 270

  Fly   235 FRKIKSGIF---PIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWF----------QKDLPA 286
            .::|.:|.:   |.|    .....|:..:|.|:|.:||.:|::..|.|.          |:.|..
Mouse   271 VKQISNGAYREPPKP----SDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYTTGVGEQEALRE 331

  Fly   287 YLFPSSIEQDSNVIDTYA---------VAEVCTKF------------------GVKETEVHNSL- 323
            ...||.....:::.|...         .|:||:.|                  .:|::...|.:
Mouse   332 GGHPSGDFGRASMADWLRRSSRPLLENGAKVCSFFKQHVPGGGSTVPGLERQHSLKKSRKENDMA 396

  Fly   324 --LSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLAT 386
              |.|||                 |:|.:             |.|......:|:..:..:
Mouse   397 QNLQGDP-----------------AEDTS-------------SRPGKSSLKLPKGILKKK----- 426

  Fly   387 VTVGGGTSASSGTA-------TPVPPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAF 444
                  :|.|||..       .|||... |.|...:.:.|....:...|.|:       ||..:.
Mouse   427 ------SSTSSGEVQEDPQELRPVPDTP-GQPVPAVSLLPRKGILKKSRQRE-------SGYYSS 477

  Fly   445 PEKTARG-----------GTPIKRAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRV 498
            ||.:..|           |.|::          |..|....|.::|.                .:
Mouse   478 PEPSESGELLDASDVFVSGDPVE----------QKSPQASGLLLHRK----------------GI 516

  Fly   499 RRQNVKTGKFSKMSLQ 514
            .:.|   ||||:.:|:
Mouse   517 LKLN---GKFSRTALE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	120/266 (45%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	13/92 (14%)
		AMPKA_C	457..580	CDD:213378	10/58 (17%)
Nuak2	NP_001181954.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		3/8 (38%)
		PKc_like	53..315	CDD:304357	120/266 (45%)
		S_TKc	57..315	CDD:214567	119/262 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..485		27/161 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..575		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910