DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and Tssk4

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001240817.1	Gene:	Tssk4 / 71099	MGIID:	1918349	Length:	338	Species:	Mus musculus

Alignment Length:	320	Identity:	110/320 - (34%)
Similarity:	168/320 - (52%)	Gaps:	39/320 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AEAVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGK- 72
            :|..:|..|....:.:.| |.:|..:|.|::|.|....:...:|.|||||::::| .|.|.:.|
Mouse     7 SETASATPAYRSVMEEYG-YEVGKIIGHGSYGTVYEAYYTKQKVMVAVKIISKKK-ASEDYLNKF 69

  Fly    73 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIIS 137
            :.||||.:|:.||.::|..||.|.|.|.:::|:|...||::.::|.::|...|..|.::|.|:..
Mouse    70 LPREIQVMKVLRHKYLINFYQAIETTSRVYIILELAQGGDVLEWIQRYGACAETLAGKWFSQMAL 134

  Fly   138 GVDYCHRHMIVH----------RDLKPENLLLDHNMHVKIADFGLSNMMLDGE------------ 180
            |:.|.|...|||          ||||.||||||...:|||:|||.:.|:...:
Mouse   135 GIAYLHSKGIVHRLTPSLSAAGRDLKLENLLLDKRENVKISDFGFAKMVPSSQPVHSSPSYRQMN 199

  Fly   181 ----FLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSG 241
                ..:|.|||..||.||::.|..|.....|.||.|||||.|:...|||||.::..|.|:.:..
Mouse   200 SLSHLSQTYCGSFAYACPEILLGLPYNPFLSDTWSMGVILYTLVVARLPFDDTNLKKLLRETQKE 264

  Fly   242 I-FPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAYLFPSSIEQDSNVI 300
            : ||....::::..||:.|:|: ...|||.|.::.:..|..|..|        ||.||.|
Mouse   265 VTFPANLTISQECKNLILQLLR-QSTKRATILDVLRDPWMLKFQP--------EQPSNEI 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	99/282 (35%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	3/4 (75%)
		AMPKA_C	457..580	CDD:213378
Tssk4	NP_001240817.1	STKc_TSSK4-like	24..302	CDD:271064	99/280 (35%)
Tssk4	NP_001240817.1	S_TKc	25..303	CDD:214567	98/279 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910