DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and Sik3

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_081774.3	Gene:	Sik3 / 70661	MGIID:	2446296	Length:	1369	Species:	Mus musculus

Alignment Length:	458	Identity:	168/458 - (36%)
Similarity:	245/458 - (53%)	Gaps:	53/458 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AAAAEAVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVV 70
            ||......|.::.|....:||:|.:..|:|.|.|..||...|.:|:.|||:||:::.::.. :.:
Mouse    44 AAVPARPTAPASRGSMAARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKSQLDE-ENL 107

  Fly    71 GKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQI 135
            .||.||:|.:|:..|||||:||||:.|...|:::.||.||||:||::|.||::.|.:|||.|:||
Mouse   108 KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQI 172

  Fly   136 ISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGK 200
            ::.|.:||...|||||||.||||||.|:::||||||.||:...|:.|:|.||||.|||||:..||
Mouse   173 VTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGK 237

  Fly   201 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDP 265
            .|.||:|||||.||:||.|:||.||||...:..|..::.||.|.||.:::.:..:|:..||.:||
Mouse   238 EYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 302

  Fly   266 LKRANIEEIKKHEWFQ--------KDLPAYLFPSSIEQDSNVI--DTYAVAEVCTKFGVKETEVH 320
            .||.::|:|.:|:|.:        ..|.|.......|:.|:.:  |.....|   ..|:.:....
Mouse   303 NKRLSMEQICRHKWMKLGDADPNFDRLIAECQQLKEERQSDPLNDDVLLAME---DMGLDKERTL 364

  Fly   321 NSLLSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLA 385
            .||.| |.:|..:..|.|:.|..:......                |...|.:|| :|..|||:.
Mouse   365 QSLRS-DAYDHYSAIYSLLCDRHKKHKTLR----------------PGALPSMPQ-AMTFQAPVN 411

  Fly   386 TVTVGGGTSASSGTATPVPPVAGGTPSSTI-------------PIRPHPERIAPMRDRQLAMSVQ 437
            ......||:.:    ..||.|....|.:.|             ...|.||.:.    |.|:|...
Mouse   412 LQAEQTGTAMN----LSVPQVQLINPENQIIEPDGAVNLDSDEGEEPSPEALV----RYLSMRRH 468

  Fly   438 TSG 440
            |.|
Mouse   469 TVG 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	125/254 (49%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	12/64 (19%)
		AMPKA_C	457..580	CDD:213378
Sik3	NP_081774.3	STKc_SIK	65..317	CDD:270973	123/252 (49%)
		S_TKc	66..317	CDD:214567	123/251 (49%)
		UBA_SIK3	346..390	CDD:270593	11/47 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910