DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and Sik3

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001258145.2	Gene:	Sik3 / 684112	RGDID:	1593938	Length:	1369	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	166/456 - (36%)
Similarity:	245/456 - (53%)	Gaps:	49/456 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AAAAEAVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVV 70
            ||......|.::.|....:||:|.:..|:|.|.|..||...|.:|:.|||:||:::.::.. :.:
  Rat    44 AACPPRPTAPASRGSMAARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDE-ENL 107

  Fly    71 GKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQI 135
            .||.||:|.:|:..|||||:||||:.|...|:::.||.||||:||::|.||::.|.:|||.|:||
  Rat   108 KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQI 172

  Fly   136 ISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGK 200
            ::.|.:||...|||||||.||||||.|:::||||||.||:...|:.|:|.||||.|||||:..||
  Rat   173 VTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGK 237

  Fly   201 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDP 265
            .|.||:|||||.||:||.|:||.||||...:..|..::.||.|.||.:::.:..:|:..||.:||
  Rat   238 EYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 302

  Fly   266 LKRANIEEIKKHEWFQ--------KDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNS 322
            .||.::|:|.:|.|.:        :.|.|.......|:.:..::. .|.......|:.:.....|
  Rat   303 NKRLSMEQICRHRWMKLGDADPNFERLIAECQQLKEERQAEPLND-EVLLAMEDMGLDKERTLQS 366

  Fly   323 LLSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATV 387
            |.| |.:|..:..|.|:.|.           ::.|.....|:.|..|      .:|..|||:...
  Rat   367 LRS-DAYDHYSAIYSLLCDR-----------HKKNKTLRPGALPSTP------QAMTFQAPVNIQ 413

  Fly   388 TVGGGTSASSGTATPVPPVAGGTPSSTI-------------PIRPHPERIAPMRDRQLAMSVQTS 439
            ....||:.:    ..||.|....|.:.|             ...|.||.:.    |.|:|...|.
  Rat   414 AEQTGTAMN----ISVPQVQLINPENQIIEPDGAVNLDSDEGEEPSPEALV----RYLSMRRHTV 470

  Fly   440 G 440
            |
  Rat   471 G 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	125/254 (49%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	11/62 (18%)
		AMPKA_C	457..580	CDD:213378
Sik3	NP_001258145.2	STKc_SIK	65..317	CDD:270973	123/252 (49%)
Sik3	NP_001258145.2	UBA_like_SF	346..390	CDD:419673	10/56 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910