Protein Alignment AMPKalpha and Prkaa1

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_062015.2
• Gene: Prkaa1 / 65248
• RGDID: 3387
• Length: 559
• Species: Rattus norvegicus
• Alignment Length: 596
• Identity: 339/596 - (56%)
• Similarity: 408/596 - (68%)
• Gaps: 94/596 - (15%)

  Fly    23 VKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPH 87
            ||||||:||.|||.|||||||:|:|::|..||||||||||||:||||||||||||||||||||||
  Rat    22 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86

  Fly    88 IIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDL 152
            ||||||||||||||||:|||||||||||||.|:|:|.|.::||.||||:||||||||||:|||||
  Rat    87 IIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDL 151

  Fly   153 KPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILY 217
            ||||:|||.:|:.|||||||||||.||||||||||||||||||||||:|||||||||||.|||||
  Rat   152 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILY 216

  Fly   218 ALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQK 282
            |||||||||||:||||||:||..|||..|:|||..|::|:..||||||:|||.|::|::||||::
  Rat   217 ALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQ 281

  Fly   283 DLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFAD 347
            |||.||||......|.:||..|:.|||.||...|.||.:.|.:.:..|.||:||||||||:|.
  Rat   282 DLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRI-- 344

  Fly   348 DAANQINEINNFFVAGSPPPPPPPPVPQSSM-DHQAPLATVTVGGGTSASSGTATPVPPVAGGTP 411
                 :||..:|::|.||        |.|.: ||..
  Rat   345 -----MNEAKDFYLATSP--------PDSFLDDHHL----------------------------- 367

  Fly   412 SSTIPIRPHPERIAPM-----RDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQSKPN 471
                 .||||||:..:     |.|.....:.       |:|:...|  :::|||||||||||:||
  Rat   368 -----TRPHPERVPFLVAETPRARHTLDELN-------PQKSKHQG--VRKAKWHLGIRSQSRPN 418

  Fly   472 DIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTNDEVE 536
            |||.||.||:|.|.||||::|||::||||:|..|..||||||||||||:::|||||:|:.::..|
  Rat   419 DIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITE 483

  Fly   537 --------------------QGDDVIME--------SLTPPPLSV-SGVMPLQP-TGHHTMEFFE 571
                                |..|...|        |||....|: |..:.:.| .|.||:||||
  Rat   484 AKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSEVSLTSSVTSLDSSPVDVAPRPGSHTIEFFE 548

  Fly   572 MCAALIIQLAR 582
            |||.||..||:
  Rat   549 MCANLIKILAQ 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	205/254 (81%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	27/62 (44%)
		AMPKA_C	457..580	CDD:213378	75/152 (49%)
Prkaa1	NP_062015.2	STKc_AMPK_alpha	24..279	CDD:270981	205/254 (81%)
		UBA_AID_AAPK1	296..360	CDD:270586	32/78 (41%)
		AIS. /evidence=ECO:0000250|UniProtKB:Q13131	302..381		38/127 (30%)
		AMPKA1_C	404..557	CDD:213384	75/152 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	484..536		8/51 (16%)