Protein Alignment AMPKalpha and prkaa2

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_700831.4
• Gene: prkaa2 / 572074
• ZFINID: ZDB-GENE-081120-5
• Length: 553
• Species: Danio rerio
• Alignment Length: 599
• Identity: 361/599 - (60%)
• Similarity: 418/599 - (69%)
• Gaps: 95/599 - (15%)

  Fly    23 VKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPH 87
            ||||||:||.|||.||||||||||||:|..||||||||||||:||||||||:|||||||||||||
Zfish    11 VKIGHYILGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75

  Fly    88 IIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDL 152
            |||||||||||:|.||:|||||||||||||.|||::::.:|||.||||||.||||||||:|||||
Zfish    76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEDAEARRLFQQIISAVDYCHRHMVVHRDL 140

  Fly   153 KPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILY 217
            ||||:|||.||:.|||||||||||.||||||||||||||||||||||:|||||||||||||||||
Zfish   141 KPENVLLDGNMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILY 205

  Fly   218 ALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQK 282
            ||||||||||||||||||:||:.|:|.||||||:.|.:|:..||||||||||.|::|::||||::
Zfish   206 ALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVASLLMLMLQVDPLKRATIKDIREHEWFKQ 270

  Fly   283 DLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFAD 347
            |||.||||.....|:.|:|..||.|||.||...|.||.:||.||||.||||:||||||||:|.
Zfish   271 DLPGYLFPEDPSYDATVVDEEAVREVCEKFECTEAEVLSSLYSGDPQDQLAVAYHLIIDNRRI-- 333

  Fly   348 DAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGTPS 412
                 :|:.:.|::|.|||                          ||:......|:||
Zfish   334 -----MNQASEFYLASSPP--------------------------TSSFMEEGMPLPP------- 360

  Fly   413 STIPIRPHPERIAP-MRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQSKPNDIMLE 476
               .::|||||:.| :.|...|.....:.....|:..|     :|:|||||||||||||.|||.|
Zfish   361 ---GVKPHPERMPPLLADSPKARCPLDALNTTRPKPLA-----VKKAKWHLGIRSQSKPYDIMAE 417

  Fly   477 VYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTNDEVEQGDDV 541
            ||||||.|.||||::||||:||||:|..||.|.||||||||||.:||||||||:        ||.
Zfish   418 VYRAMKQLEYEWKVVNPYHLRVRRKNPVTGNFVKMSLQLYQVDNRSYLLDFKSI--------DDD 474

  Fly   542 IME----SLTPP--------------------------------PLSVSGVMPL--QPTGHHTME 568
            |||    |.||.                                |.|::|..||  ...|.|||:
Zfish   475 IMEHKSGSSTPQRSGSTAGLLRPRLSIDSASVVAMEMPQLSSSLPGSLTGSTPLLTPRQGSHTMD 539

  Fly   569 FFEMCAALIIQLAR 582
            ||||||:||..|||
Zfish   540 FFEMCASLITTLAR 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	210/254 (83%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	32/62 (52%)
		AMPKA_C	457..580	CDD:213378	83/160 (52%)
prkaa2	XP_700831.4	STKc_AMPK_alpha	13..268	CDD:270981	210/254 (83%)
		S_TKc	16..268	CDD:214567	207/251 (82%)
		UBA_AID_AAPK2	285..349	CDD:270587	37/96 (39%)
		AMPKA_C_like	394..551	CDD:302605	85/169 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575779
Domainoid	1	1.000	437	1.000	Domainoid score	I543
eggNOG	1	0.900	-	-		E33208_3BB6Z
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4551
Inparanoid	1	1.050	677	1.000	Inparanoid score	I697
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275232at33208
OrthoFinder	1	1.000	-	-		FOG0000976
OrthoInspector	1	1.000	-	-		otm24319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1362
SonicParanoid	1	1.000	-	-		X997
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.890