Protein Alignment AMPKalpha and sik2b

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_696325.5
• Gene: sik2b / 567919
• ZFINID: ZDB-GENE-071012-1
• Length: 896
• Species: Danio rerio
• Alignment Length: 613
• Identity: 191/613 - (31%)
• Similarity: 294/613 - (47%)
• Gaps: 139/613 - (22%)

  Fly    23 VKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPH 87
            |::|.|.:..|||.|.|..||:..|:||:.:||:||:::.::.::: :.||.||:|.:|:..|||
Zfish    17 VRVGFYDIERTLGKGNFAVVKLARHRITKTEVAIKIIDKTQLDAVN-LEKIYREVQIMKMLDHPH 80

  Fly    88 IIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDL 152
            |||||||:.|.:.::::.||...||:|||:.|||:|.|.:|||.|.||:|.|:|||...||||||
Zfish    81 IIKLYQVMETKNMLYLVTEYAKNGEIFDYLAKHGRLSEPEARRKFWQILSAVEYCHNRNIVHRDL 145

  Fly   153 KPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILY 217
            |.||||||.:|::||||||..|....|:.|.|.||||.||||||..|:.|.||::||||.||:||
Zfish   146 KAENLLLDGHMNIKIADFGFGNFFQSGKPLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLY 210

  Fly   218 ALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQK 282
            .|:||.||||...:|.|.:::..|.|.||.::.:...:|:.:||.:||.||.:|.:||:|:|...
Zfish   211 VLVCGALPFDGPSLPVLRQRVLEGRFRIPYFMTEDCEHLIRRMLVLDPSKRLSIGQIKEHKWMVM 275

  Fly   283 DLPA---YLFPSSIEQDSNVID-TYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIID-- 341
            ::|.   .|:..:.|.::.|.: ...|..:....|:.:.:...| |....::..|..|:|:::
Zfish   276 EVPVQRPMLYQQTTEGEAGVGEYNEQVLRLMHSLGIDQHKTVES-LQNKSYNHFAAIYYLLVERL 339

  Fly   342 ---------------NKRFADDAANQINEINNFFVAGSPPPPP------------PPPVPQSSMD 379
                           .:|.....|.|.      .|..|...|.            ||.|||:|.|
Zfish   340 KAHRCSFPVEPRLDARQRRPSTIAEQT------LVKASSAAPQVSLLPQNVRLLRPPAVPQTSAD 398

  Fly   380 ----------------HQAPLATVTVGGGTSASSGTATPVPPVAGGTPSSTIPIRPHPERIAPMR 428
                            .:..:.|..:.|      ....|:||||....|::.|        :.|.
Zfish   399 SFTFPQSSCAAEHSLMEEEEVGTPKING------CMLDPLPPVAVRKSSASSP--------SNMM 449

  Fly   429 DRQLAMSVQTSGGGAFPE------------KTARGGTPIKRAKWHLGIRSQSKPNDIMLEVYRAM 481
            :..:...::|..    |:            :|||.|     .:.|......::|..|
Zfish   450 ETSIDEGIETEE----PDTEDDHTHVFNAYQTARFG-----QRRHTLSEVTNQPGII-------- 497

  Fly   482 KALSYEWKIINPYHVRVRRQNVKTGKFSKM--SLQLYQVDAKSYLLDFKSLTND--EVEQG---D 539
                                 ...||...|  :..|..||::   .|..|:.:|  .:|.|   :
Zfish   498 ---------------------TSGGKLFSMGHNPSLGSVDSE---YDMGSMHSDLSLLEDGPSLN 538

  Fly   540 DVIMES-----LTPPPLSVSGVMPLQPT 562
            :|::.:     ||||.:|   ..|..||
Zfish   539 EVVLANTPVTRLTPPFIS---ARPANPT 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	126/254 (50%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	11/80 (14%)
		AMPKA_C	457..580	CDD:213378	23/118 (19%)
sik2b	XP_696325.5	STKc_SIK	21..273	CDD:270973	125/252 (50%)
		S_TKc	22..273	CDD:214567	125/251 (50%)
		UBA_SIK2	299..343	CDD:270592	7/44 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910