DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and brsk1a

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_693123.4	Gene:	brsk1a / 564701	ZFINID:	ZDB-GENE-121214-354	Length:	746	Species:	Danio rerio

Alignment Length:	515	Identity:	184/515 - (35%)
Similarity:	269/515 - (52%)	Gaps:	84/515 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHII 89
            :|.|.|..|||.|..|.||:|.|.||..|||:||:||:|: |..|:.|:.|||..|||..|||::
Zfish    14 VGPYRLEKTLGKGQTGLVKLGIHCITSQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPHVL 77

  Fly    90 KLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKP 154
            ||:.|......:::::|:|||||||||:||.|:|...:||:||:||||.:|:||.|.|.||||||
Zfish    78 KLHDVYENNKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKP 142

  Fly   155 ENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYAL 219
            ||||||...:::|||||::::.:....|.||||||:||.||||.|:.|.|...|:|||||||:||
Zfish   143 ENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRRADVWSCGVILFAL 207

  Fly   220 LCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQ--K 282
            |.|.||||.:::..|..|:|||:|.:|.::......|:..|::|:|.||..:|.|:||.|:|  :
Zfish   208 LVGALPFDHDNLRQLLEKVKSGVFHMPHFIPPDCQALLRGMIEVNPEKRLTLEAIQKHAWYQAGR 272

  Fly   283 DLPAYLFP-----------SSIEQDSNVIDT-YAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIA 335
            :.|....|           |..|.|.:|:|: |::.  |.:..||..:.    |..:..:|..:.
Zfish   273 NEPCPEQPPPRRVSMGRIMSLTELDPDVLDSMYSLG--CFRDRVKLAQD----LQCEEDNQEKMI 331

  Fly   336 YHLIIDNKR----FADD---AANQIN------------------------EINNFFVAGSPPPPP 369
            |:|::|.|.    :.|:   ..|.::                        |:.:....|||.|
Zfish   332 YYLLLDRKERYPSYEDEDLPPRNDVDPPRKRVDSPMLTRHGRCRPERKSLEVLSVTEQGSPTP-- 394

  Fly   370 PPPVPQSSMD---HQAPLATVTVGGGTSASSG---------TATPVPPVAGGTPSSTIPIRPHPE 422
                |:.::|   |.....:|: |..|..||.         ..:|:|     ||..|....|||.
Zfish   395 ----PRRALDTSTHSQRSRSVS-GASTGLSSSPLSSPRVTPQGSPLP-----TPLGTPVHHPHPP 449

  Fly   423 RIAPMRDRQLAMSVQTSGGGAF--------PEKTARGGTPIKRAKWHLGIRSQSKPNDIM 474
            ...|......:.|.:..|||..        |.....||.....:..|...|..|..|:::
Zfish   450 TATPPSSSSSSSSSRAEGGGVGVGSLSLTPPSSPGGGGGMAASSSAHWRTRLNSLKNNLL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	130/254 (51%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	15/94 (16%)
		AMPKA_C	457..580	CDD:213378	4/18 (22%)
brsk1a	XP_693123.4	STKc_BRSK1_2	15..268	CDD:270983	130/253 (51%)
		S_TKc	17..267	CDD:214567	129/250 (52%)
		UBA_BRSK	295..348	CDD:270525	14/58 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910