Protein Alignment AMPKalpha and nuak1b

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_689990.3
• Gene: nuak1b / 561496
• ZFINID: ZDB-GENE-131120-18
• Length: 613
• Species: Danio rerio
• Alignment Length: 571
• Identity: 169/571 - (29%)
• Similarity: 260/571 - (45%)
• Gaps: 122/571 - (21%)

  Fly    28 YLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLY 92
            |.|..|||.||:|||:....:.:..:||:|.:.::|||....:..|||||:.:...||||||.:|
Zfish    48 YELLETLGRGTYGKVRKAIERHSGREVAIKSIRKEKIKDEQDMVHIRREIEIMSSLRHPHIISIY 112

  Fly    93 QVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENL 157
            :|......|.::|||.|.|||:|||.:..:|.|.:.|.||:||:|.|.|||::.:||||||.||:
Zfish   113 EVFENKDKIVIVMEYASKGELYDYISERRRLTERETRHFFRQIVSAVHYCHKNGVVHRDLKLENV 177

  Fly   158 LLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCG 222
            |||.|.::|||||||||:....:.|:|.||||.||:||:::|:.|.|||||.|:.||:||.|:.|
Zfish   178 LLDENCNIKIADFGLSNLYHKDKLLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYG 242

  Fly   223 TLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWF------- 280
            ::|||......|.|:|.:|.:..|.. :.....|:..||.|:|.:||.:|:|..|.|.
Zfish   243 SMPFDGGDHKNLIRQISNGEYREPSQ-SSDARGLIRWMLMVNPERRATVEDIANHWWVNWGWKNS 306

  Fly   281 ------QKDLPAYLFPSSIEQDSNV---------IDTYAVAEVCTKFGVKETEVHNSLLSGDPHD 330
                  |:|..:.:....|:..:..         .:.:.:.....|...||.:|..|..:|:  |
Zfish   307 VCDCESQRDNGSPMLARLIDWQNRTEPRPTKAIRSEPFLLVRQRPKKSKKENDVGVSHCNGE--D 369

  Fly   331 QLAIAYHL-IIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTS 394
            .|.:.... |:..:...:..:..:.||.:  .||:|.....|.......:.
Zfish   370 SLGLKRPKGILKTRTSEEQRSPSLEEIES--GAGTPEKESGPDGEDGDEEQ-------------- 418

  Fly   395 ASSGTATPVPPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKT----------- 448
                         |.:||.::.|.|....:...:.|:       ||..:.||::
Zfish   419 -------------GNSPSKSVSILPKKGILKNNQQRE-------SGYYSSPERSESSDLLSGNIT 463

  Fly   449 -ARGGTPIKRAKWHLGI------------------------------RSQSKPNDIMLEVYRAMK 482
             ....:|.|||....||                              ||||:|:.|:.|....:.
Zfish   464 PLAASSPPKRAVGRKGILKRNGKYSTYSGAPPLGVLGEPAPSDSGLSRSQSRPSSIVREDSDTIT 528

  Fly   483 ALSY---EWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSL 530
            ..|:   ||.   |...   |.|:::...::..||         |.:||.|
Zfish   529 NSSFCSTEWP---PPRT---RPNIRSCLSAENLLQ---------LANFKGL 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	115/251 (46%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	11/72 (15%)
		AMPKA_C	457..580	CDD:213378	23/107 (21%)
nuak1b	XP_689990.3	None