DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and nuak2

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_688764.3	Gene:	nuak2 / 560275	ZFINID:	ZDB-GENE-050208-563	Length:	576	Species:	Danio rerio

Alignment Length:	435	Identity:	147/435 - (33%)
Similarity:	209/435 - (48%)	Gaps:	89/435 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQVIST 97
            |||.||:|:||....: :...||:|.:.::||:....:..|||||:.:....|||||.:|:|...
Zfish    34 TLGKGTYGRVKKAMDR-SGTAVAIKSIRKEKIRDEQELTHIRREIEIMSSLSHPHIISIYEVFEN 97

  Fly    98 PSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHN 162
            ...|.::||..|.|:|||||.....|.|.|||.||:||:|.|.||||:.|||||||.||:|||.|
Zfish    98 KDKIVIVMELASRGDLFDYICDSQPLAETQARHFFRQIVSAVHYCHRNGIVHRDLKLENILLDCN 162

  Fly   163 MHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFD 227
            .::|||||||||:....:.|:|.||||.||:||:::|:.|.|||||.||.||:||.|:.|.:|||
Zfish   163 GNIKIADFGLSNLYRGDKLLQTYCGSPLYASPEIVNGRPYRGPEVDSWSLGVLLYTLMHGAMPFD 227

  Fly   228 DEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEW----FQKDL---- 284
            ......|.::|.||.:..|. .......|:..||.|:|.:||.:|:|..|.|    |:..|
Zfish   228 GHDHRILVQQISSGSYRKPS-KPSDACGLIRWMLMVNPERRATLEDIAGHWWVNWGFELPLLAQS 291

  Fly   285 -PAYLFPSS-----IEQDSN--------------VIDTYAVAEVCTKFGV------------KET 317
             ||...|:|     :.|.:.              ::::.:......:.|.            ||.
Zfish   292 DPATAHPASEPAAVVSQTNGSTRIADWLRRSSRPLLESSSKMRCLLRTGEPVQRQRSIRRSRKEN 356

  Fly   318 EVHNSL------------------LSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGS 364
            .:..|:                  |...|..||.     .::.|.            :|..||..
Zfish   357 NISQSMQETPRPAKGILKKRGSLKLKAPPEPQLT-----PLEEKS------------SNALVAAV 404

  Fly   365 PPPPP-----PPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVP 404
            .||||     .|...:||....:|       ..:..:.|..:|||
Zfish   405 LPPPPKGILKKPSESESSCCSLSP-------QNSGQTLGNPSPVP 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	116/250 (46%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	10/106 (9%)
		AMPKA_C	457..580	CDD:213378
nuak2	XP_688764.3	STKc_NUAK2	25..279	CDD:271063	115/246 (47%)
nuak2	XP_688764.3	S_TKc	29..279	CDD:214567	115/246 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910