Protein Alignment AMPKalpha and brsk1b

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_009297839.1
• Gene: brsk1b / 558390
• ZFINID: ZDB-GENE-131122-54
• Length: 862
• Species: Danio rerio
• Alignment Length: 500
• Identity: 176/500 - (35%)
• Similarity: 261/500 - (52%)
• Gaps: 90/500 - (18%)

  Fly    25 IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHII 89
            :|.|.|..|||.|..|.||:|.|.||..|||:||:||:|: |..|:.|:.|||..|||..|||::
Zfish    15 VGPYRLEKTLGKGQTGLVKLGVHCITTQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPHVL 78

  Fly    90 KLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKP 154
            |||.|......:::::|:|||||||||:||.|:|...:||:||:||||.:|:||.|.|.||||||
Zfish    79 KLYDVYENNKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKP 143

  Fly   155 ENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYAL 219
            ||||||...:::|||||::::.:....|.||||||:||.||||.|:.|.|...|:|||||||:||
Zfish   144 ENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRRADVWSCGVILFAL 208

  Fly   220 LCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQ--K 282
            |.|.||||.:::..|..|:|||:|.:|.::......|:..|::|:..||..:|||:||.|:|  :
Zfish   209 LVGALPFDHDNLRQLLEKVKSGVFHMPHFIPPDCQALLRGMIEVNAEKRLTLEEIQKHPWYQGGR 273

  Fly   283 DLPAYLFP-----------SSIEQDSNVIDT-YAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIA 335
            :.|....|           |..:.|.:|::: :::.  |.:..||.|..    |..:..:|..:.
Zfish   274 NEPCPEQPPPRRVCVKRILSLTDLDPDVLESMHSLG--CFRDRVKLTRD----LQCEEENQEKLI 332

  Fly   336 YHLIIDNKR----FADD---AANQIN------------------------EINNFFVAGSPPPPP 369
            |:|::|.|.    :.|:   ..|.::                        |:.:....|||.|
Zfish   333 YYLLLDRKERYPSYEDEHLPPRNDVDPPRKRVDSPMLTRHGRCRPERKSLEVLSVTEQGSPTP-- 395

  Fly   370 PPPVPQSSMDHQA----------------------PLATVTVGGGTSASSGTAT-PVPPVAGGTP 411
                |:.::|..|                      |.:.|.....|..:|.:|| ...|.||
Zfish   396 ----PRRALDTSAHSQRSRSVSGASTGLSSSPLSSPRSPVFTFSQTEVTSASATQSKDPKAG--- 453

  Fly   412 SSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTPIK 456
            |||.|      |.:.....|...::.|......|...:....|::
Zfish   454 SSTTP------RASQRAPEQKTQTLPTKAASDRPHLQSMKSLPLQ 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	131/254 (52%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	14/94 (15%)
		AMPKA_C	457..580	CDD:213378	176/499 (35%)
brsk1b	XP_009297839.1	STKc_BRSK1_2	16..269	CDD:270983	131/253 (52%)
		UBA_BRSK	296..349	CDD:270525	12/58 (21%)