DRSC/TRiP Functional Genomics Resources

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Protein Alignment AMPKalpha and PRKAA2

DIOPT Version :9

Sequence 1:NP_477313.1 Gene:AMPKalpha / 43904 FlyBaseID:FBgn0023169 Length:582 Species:Drosophila melanogaster
Sequence 2:NP_006243.2 Gene:PRKAA2 / 5563 HGNCID:9377 Length:552 Species:Homo sapiens


Alignment Length:589 Identity:357/589 - (60%)
Similarity:419/589 - (71%) Gaps:76/589 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 VKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPH 87
            ||||||:||.|||.||||||||||||:|..||||||||||||:||||||||:|||||||||||||
Human    11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75

  Fly    88 IIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDL 152
            |||||||||||:|.||:|||||||||||||.|||:::|.:|||.||||:|.||||||||:|||||
Human    76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140

  Fly   153 KPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILY 217
            ||||:|||.:|:.|||||||||||.||||||||||||||||||||||:|||||||||||||||||
Human   141 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILY 205

  Fly   218 ALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQK 282
            ||||||||||||||||||:||:.|:|.||||||:.|..|:..||||||||||.|::|::||||::
Human   206 ALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270

  Fly   283 DLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFAD 347
            |||:||||.....|:||||..||.|||.||...|:||.|||.||||.||||:||||||||:|.  
Human   271 DLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRI-- 333

  Fly   348 DAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGTPS 412
                 :|:.:.|::|.|||       ..|.||                  .:|..:||       
Human   334 -----MNQASEFYLASSPP-------SGSFMD------------------DSAMHIPP------- 361

  Fly   413 STIPIRPHPERIAPM-RDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQSKPNDIMLE 476
               .::|||||:.|: .|...|.....:.....|:..|     :|:|||||||||||||.|||.|
Human   362 ---GLKPHPERMPPLIADSPKARCPLDALNTTKPKSLA-----VKKAKWHLGIRSQSKPYDIMAE 418

  Fly   477 VYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTNDEVEQ--GD 539
            ||||||.|.:|||::|.||:||||:|..||.:.|||||||.||.:||||||||:.::.|||  |.
Human   419 VYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGS 483

  Fly   540 DV---------------IMESLTPPPLSVSGVMPLQPT-----------GHHTMEFFEMCAALII 578
            ..               ..:|.|....|:||.:....|           |.|||:||||||:||.
Human   484 STPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLIT 548

  Fly   579 QLAR 582
            .|||
Human   549 TLAR 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AMPKalphaNP_477313.1 STKc_AMPK_alpha 25..280 CDD:270981 209/254 (82%)
UBA_AID_AMPKalpha 297..360 CDD:270521 35/62 (56%)
AMPKA_C 457..580 CDD:213378 76/150 (51%)
PRKAA2NP_006243.2 STKc_AMPK_alpha 13..268 CDD:270981 209/254 (82%)
UBA_AID_AAPK2 285..349 CDD:270587 40/77 (52%)
AIS. /evidence=ECO:0000250 291..376 48/126 (38%)
AMPKA2_C 395..550 CDD:213385 78/159 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..521 9/43 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142939
Domainoid 1 1.000 436 1.000 Domainoid score I573
eggNOG 1 0.900 - - E33208_3BB6Z
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4551
Inparanoid 1 1.050 670 1.000 Inparanoid score I744
Isobase 1 0.950 - 0 Normalized mean entropy S655
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D275232at33208
OrthoFinder 1 1.000 - - FOG0000976
OrthoInspector 1 1.000 - - otm41791
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR24343
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1362
SonicParanoid 1 1.000 - - X997
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.840

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