Protein Alignment AMPKalpha and PRKAA1

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_996790.3
• Gene: PRKAA1 / 5562
• HGNCID: 9376
• Length: 574
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 339/611 - (55%)
• Similarity: 408/611 - (66%)
• Gaps: 109/611 - (17%)

  Fly    23 VKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPH 87
            ||||||:||.|||.|||||||:|:|::|..||||||||||||:||||||||||||||||||||||
Human    22 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86

  Fly    88 IIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGK---------------LQEHQARRFFQQIIS 137
            ||||||||||||||||:|||||||||||||.|:|:               |.|.::||.||||:|
Human    87 IIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILS 151

  Fly   138 GVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLY 202
            |||||||||:|||||||||:|||.:|:.|||||||||||.||||||||||||||||||||||:||
Human   152 GVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 216

  Fly   203 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLK 267
            |||||||||.||||||||||||||||:||||||:||..|||..|:|||..|::|:..||||||:|
Human   217 AGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMK 281

  Fly   268 RANIEEIKKHEWFQKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQL 332
            ||.|::|::||||::|||.||||......|.:||..|:.|||.||...|.||.:.|.:.:..|.|
Human   282 RATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPL 346

  Fly   333 AIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSM-DHQAPLATVTVGGGTSAS 396
            |:||||||||:|.       :||..:|::|.||        |.|.: ||..
Human   347 AVAYHLIIDNRRI-------MNEAKDFYLATSP--------PDSFLDDHHL-------------- 382

  Fly   397 SGTATPVPPVAGGTPSSTIPIRPHPERIAPM-----RDRQLAMSVQTSGGGAFPEKTARGGTPIK 456
                                .||||||:..:     |.|.....:.       |:|:...|  ::
Human   383 --------------------TRPHPERVPFLVAETPRARHTLDELN-------PQKSKHQG--VR 418

  Fly   457 RAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAK 521
            :|||||||||||:|||||.||.||:|.|.||||::|||::||||:|..|..:|||||||||||::
Human   419 KAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSR 483

  Fly   522 SYLLDFKSLTNDEVE--------------------QGDDVIME--------SLTPPPLSV-SGVM 557
            :|||||:|:.::..|                    |..|...|        |||....|: |..:
Human   484 TYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPV 548

  Fly   558 PLQP-TGHHTMEFFEMCAALIIQLAR 582
            .|.| .|.||:|||||||.||..||:
Human   549 DLTPRPGSHTIEFFEMCANLIKILAQ 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	205/269 (76%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	27/62 (44%)
		AMPKA_C	457..580	CDD:213378	75/152 (49%)
PRKAA1	NP_996790.3	STKc_AMPK_alpha	24..294	CDD:270981	205/269 (76%)
		UBA_AID_AAPK1	311..375	CDD:270586	32/78 (41%)
		AMPKA1_C	419..572	CDD:213384	75/152 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	436	1.000	Domainoid score	I573
eggNOG	1	0.900	-	-		E33208_3BB6Z
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	670	1.000	Inparanoid score	I744
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275232at33208
OrthoFinder	1	1.000	-	-		FOG0000976
OrthoInspector	1	1.000	-	-		otm41791
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1362
SonicParanoid	1	1.000	-	-		X997
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.960