Protein Alignment AMPKalpha and sik1

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001119855.1
• Gene: sik1 / 553465
• ZFINID: ZDB-GENE-030131-9446
• Length: 811
• Species: Danio rerio
• Alignment Length: 598
• Identity: 191/598 - (31%)
• Similarity: 287/598 - (47%)
• Gaps: 118/598 - (19%)

  Fly    17 ANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITR-----------VKVAVKILNRQKIKSLDVV 70
            |..:|| ::|.|.:..|||.|.|..||:..|::|:           ::||:||:::.::.|.: :
Zfish    16 AQARPL-QVGFYEIIRTLGKGNFAVVKLARHKVTKTQAITTFYFIFMQVAIKIIDKTRLNSAN-L 78

  Fly    71 GKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQI 135
            .||.||:|.:||..||||||||||:.|...::::.||...||:|||:..:|::.|::||:.|.||
Zfish    79 EKIYREVQIMKLLNHPHIIKLYQVMETKDMLYIVTEYAKNGEMFDYLTSNGRMSENEARKKFWQI 143

  Fly   136 ISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGK 200
            ::.|||||||.|||||||.||||||.||::|:||||..|....||.|.|.||||.||||||..||
Zfish   144 LTAVDYCHRHHIVHRDLKTENLLLDANMNIKLADFGFGNFYNAGEPLSTWCGSPPYAAPEVFEGK 208

  Fly   201 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDP 265
            .|.||::||||.||:||.|:||:||||.:.:|.|.:::..|.|.||.::::...||:.:||.|||
Zfish   209 EYEGPQLDIWSLGVVLYVLVCGSLPFDGDSLPALRQRVTEGRFRIPFFMSQDCENLIRKMLVVDP 273

  Fly   266 LKRANIEEIKKHEWFQKDLPA---YLFPSSIEQDSNVID-TYAVAEVCTKFGVKETEVHNSLLSG 326
            .||..|.:||:|.|...|..|   .|..|..:.:||:.| :..|..:....|:.......| |..
Zfish   274 AKRITIAQIKQHRWMLADPSAPHQTLSLSLTDYNSNLGDYSEPVLGIMQTLGIDRQRTVES-LQN 337

  Fly   327 DPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGG 391
            ..::..:..|:|:::  |..:..:.||:.                   |....:|.        .
Zfish   338 SSYNHFSAIYYLLLE--RVKEHRSQQISR-------------------QCGAWNQR--------S 373

  Fly   392 GTSASSGTATPVPPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTPIK 456
            .|::.|.|...:...:....:|..|:.....  ||:..     .::...||.|..........:.
Zfish   374 RTASDSSTPEVIMESSDSFRNSAFPVATKVN--APIHS-----EMECEQGGLFQRVVCPVEASLN 431

  Fly   457 RAKWHLGIRSQS----------KPNDI-----MLEVYRAMKALSYEWKIINPYHV------RVRR 500
            ...|:..|...|          :|:|:     :|:|              .|.|:      |...
Zfish   432 GLLWNRSISPNSLLETTISEEVRPHDLEEEEGILQV--------------QPPHLPSTTSRRHTL 482

  Fly   501 QNVKTGKFSKMS---LQLYQVDAKSYLLDFKSLTNDEVEQGDDVIMESLTPPPLS---------- 552
            ..|.|.:|.:.|   :.:...|..|.....||.:|              |.||||
Zfish   483 AEVSTSRFHQCSPPCIVVSPSDGASSDSCLKSSSN--------------TNPPLSPVVGDFSSLL 533

  Fly   553 VSGVMP--LQPTG 563
            :||..|  |.|.|
Zfish   534 ISGTGPGALGPAG 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	129/265 (49%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	12/63 (19%)
		AMPKA_C	457..580	CDD:213378	30/143 (21%)
sik1	NP_001119855.1	STKc_SIK	25..288	CDD:270973	128/263 (49%)
		UBA_SIK1	309..358	CDD:270591	9/51 (18%)