Protein Alignment AMPKalpha and Smok3a

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001119517.1
• Gene: Smok3a / 545814
• MGIID: 3693943
• Length: 504
• Species: Mus musculus
• Alignment Length: 472
• Identity: 134/472 - (28%)
• Similarity: 225/472 - (47%)
• Gaps: 55/472 - (11%)

  Fly    28 YLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLY 92
            |::..|:|.|....||:.:|::|...||||.:.:::.....|:.    |::.|.:..||:||.|.
Mouse    28 YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIRKREYWCNRVIS----EVELLMMADHPNIISLL 88

  Fly    93 QVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENL 157
            |||.|...:::|||...|..|:.:|.|.|.||||:||..|:|::|.::|||...||||||||:|:
Mouse    89 QVIETKKKVYLIMELCKGKSLYQHIRKAGYLQEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNI 153

  Fly   158 LLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCG 222
            :::.:..|||.||||...:..|:.|...||:..::||||:....|.||::|:|:.||:||.::.|
Mouse   154 MVEKDGKVKIIDFGLGTKVKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKIDVWTLGVVLYFMVTG 218

  Fly   223 TLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAY 287
            .:|||...:..|.::|.:|.:.||..|:.::.:|:..::..:|..|..:.|:..|.|..:.  :.
Mouse   219 KIPFDACSIKKLVKRILAGKYSIPSRLSAELQDLLSLLMTANPKLRPTVAEVMVHPWVTEG--SG 281

  Fly   288 LFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADDAANQ 352
            :||...|:.:.:....|:.:.....|.:..::.:||.. ...:|...:|.|:........|...:
Mouse   282 VFPDPCEEQTPLKPDPAIVKAMGHIGFQAQDIEDSLRQ-RKFNQTMASYCLLKKQILKECDRPTR 345

  Fly   353 INEINNFFVAGSPPPPP-----------------PPPVPQSSMDHQAPLATVTVGGGTSASSGTA 400
            ...:|     .|..|.|                 .|..|.||.:.|..:.    |..||......
Mouse   346 ARPVN-----PSVTPFPSLVDTATTRLGLRRRENEPTCPWSSANRQVSVC----GKSTSKKRDRR 401

  Fly   401 TPVPPVAGGTPSSTIPIRPHPERIAPMRDR------QLAMSVQTSGGGAFPEKTARGGT------ 453
            ...|.|. |.|..|.|...|..    .|.|      .:..:||.:..    |::.:|.|
Mouse   402 VSWPSVL-GRPRHTAPTMDHTR----TRTRSVPCICSMFCTVQPNSS----EESTQGHTRASAAD 457

  Fly   454 -PIKRAKWHLGIRSQSK 469
             |:....|..||:..::
Mouse   458 KPVHSRGWPRGIKGWTR 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	92/251 (37%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	9/62 (15%)
		AMPKA_C	457..580	CDD:213378	3/13 (23%)
Smok3a	NP_001119517.1	STKc_AMPK-like	27..275	CDD:270905	92/250 (37%)
		UBA_MARK_Par1	295..334	CDD:270522	7/39 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..421		9/36 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..468		5/30 (17%)