DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and trbl

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_524672.1	Gene:	trbl / 43999	FlyBaseID:	FBgn0028978	Length:	484	Species:	Drosophila melanogaster

Alignment Length:	353	Identity:	93/353 - (26%)
Similarity:	148/353 - (41%)	Gaps:	73/353 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AEAVAAGSANGQPLVKI-GHYLLGATLGTGTFGKVKIGEHQITRVKVAVKI-----------LNR 61
            |..:||...:.||:..| ..||:.|               |.:.:..||..           |..
  Fly    88 ALGIAAEPTDQQPVKLIQQRYLISA---------------QPSHISAAVAAKTPASYRHLVDLTA 137

  Fly    62 QKIKSLDV--------------VGKIRR----------EIQNLKLFRHPHIIKLYQVISTPSD-I 101
            ..::.:|:              :.|::|          |::...::.||.|..::.:|....| .
  Fly   138 SNLRCVDIFTGEQFLCRIVNEPLHKVQRAYFQLQQHDEELRRSTIYGHPLIRPVHDIIPLTKDRT 202

  Fly   102 FMIMEYV------SGG------ELFDYIVKHGK-LQEHQARRFFQQIISGVDYCHRHMIVHRDLK 153
            ::::..|      :||      .|..|| :|.| |.|.:||..|.||...|..|||:.|:.||||
  Fly   203 YILIAPVPQERDSTGGVTGVYENLHTYI-RHAKRLCETEARAIFHQICQTVQVCHRNGIILRDLK 266

  Fly   154 PENLLLDHNMHVKIADFGL-SNMMLDGE--FLRTSCGSPNYAAPEVI-SGKLYAGPEVDIWSCGV 214
            .:..........|:....| .:|:||||  .|....|.|.|.|||:: ..:.|.|...|:||.||
  Fly   267 LKRFYFIDEARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPADMWSLGV 331

  Fly   215 ILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEW 279
            |||.:|.|..||.::....|...|:.|...||..|:|.|..|:..:|:.|..:|.....|....|
  Fly   332 ILYTMLVGQYPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPW 396

  Fly   280 FQKDLPAYLFPSSIEQDSNVIDTYAVAE 307
            .::..|.:::   :..|..|.:.::.||
  Fly   397 LREQRPFHMY---LPVDVEVAEDWSDAE 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	82/308 (27%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	3/11 (27%)
		AMPKA_C	457..580	CDD:213378
trbl	NP_524672.1	PKc_like	131..397	CDD:328722	75/266 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910