DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPKalpha and CG17698

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001036633.2	Gene:	CG17698 / 4379919	FlyBaseID:	FBgn0040056	Length:	694	Species:	Drosophila melanogaster

Alignment Length:	371	Identity:	110/371 - (29%)
Similarity:	173/371 - (46%)	Gaps:	75/371 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKI------------KSLDVVGKIRR 75
            :::..|.|...:|.|::|.||:...:......|:|||:::::            |:...:.::.|
  Fly   278 LQLNQYRLMEQIGQGSYGLVKLAYSEEDSTHYAMKILSKKRLLRQAGLMRRGPRKATSPLDRVYR 342

  Fly    76 EIQNLKLFRHPHIIKLYQVISTP--SDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISG 138
            ||..||...||:::||.:|:..|  ..::|:.|.|..||:. .|.....|.|.:|...|::.:.|
  Fly   343 EIAVLKKLDHPNVVKLVEVLDDPLEDSLYMVFELVKQGEVL-RIPTDNPLSEKRAWSIFRESLLG 406

  Fly   139 VDY------------------CHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFL--- 182
            ::|                  .|...|:|.|:||.||||....||||||.|:.|     |||
  Fly   407 LEYYTMLSSSAISLKRIFVYTVHHQKIIHADIKPGNLLLTEFGHVKIADLGVCN-----EFLGDD 466

  Fly   183 -----RTSCGSPNYAAPE-VISGK-LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKS 240
                 .::.|:|.:.||| :|.|: .|.|...|:|:.|..||:|:.|.:||..:.||.|:.|||.
  Fly   467 ATISNGSTAGTPAFRAPETLIPGQNEYCGRAADVWALGATLYSLIFGNVPFLADSVPLLYEKIKQ 531

  Fly   241 GIFPIPEYLNKQVVNL---VCQMLQVDPLKRANIEEIKKHEWFQKDLPAYLFPSSIEQ------- 295
            .....||. :|...||   :.|||:.:|.:|..|.::|..:|...| ..|..|:..|.
  Fly   532 DSVKFPEN-HKVTENLKSCIVQMLEKNPTQRITIPQLKTSKWVTSD-GDYPLPTEEENCCLVQVD 594

  Fly   296 ----DSNV-----IDTYAVAEVCTK---FG---VKETEVHNSLLSG 326
                ||.|     :||..:.:...|   ||   ||.....:|.|:|
  Fly   595 DEDIDSVVRSIPKLDTLILIKTMLKKHSFGNPFVKGCSGTSSSLAG 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	92/299 (31%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	12/41 (29%)
		AMPKA_C	457..580	CDD:213378
CG17698	NP_001036633.2	S_TKc	283..573	CDD:214567	92/296 (31%)
CG17698	NP_001036633.2	STKc_CAMKK	288..574	CDD:271020	91/292 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010