DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and CG14305

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_650732.1	Gene:	CG14305 / 42233	FlyBaseID:	FBgn0038630	Length:	302	Species:	Drosophila melanogaster

Alignment Length:	294	Identity:	90/294 - (30%)
Similarity:	148/294 - (50%)	Gaps:	26/294 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AAAAEAVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITR---------VKVAVKILNR 61
            :|....:...|::...|.:.| |.:|..:|.|::..|      ||.         |.:|.||:::
  Fly     7 SAGIRQLGTRSSDVDALAQRG-YNVGHKIGEGSYATV------ITAGYADDHGHGVHLACKIIDK 64

  Fly    62 QKIKSLDVVGK-IRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQE 125
            .|..: |.|.| ..||::.|....|.:||:::.::.....||:.|.|...|:|..:|.:.|.:.|
  Fly    65 AKAPT-DFVNKFFPRELEILTKIDHSNIIQIHSILQRGPKIFIFMRYAENGDLLSHIKRSGPIDE 128

  Fly   126 HQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLD--GEFLR--TSC 186
            .|::.:|.|:...:.|.|...|.|||||.||:||...:::|:||||.:....|  |..::  |.|
  Fly   129 KQSKIWFFQMSKALKYLHNLDIAHRDLKCENILLSKRLNIKLADFGFARYCRDDNGREMKSETYC 193

  Fly   187 GSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIF----PIPE 247
            ||..||||||:.|:.|.....|.||.||||:.::...:||||.::..|....::..|    .:.|
  Fly   194 GSAAYAAPEVVCGRPYDPKLADAWSLGVILFIMMNAKMPFDDSNLTKLLEDQRNRKFAFRRKLQE 258

  Fly   248 YLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQ 281
            .::.|....|..:|:.:...|.|:.||....|.:
  Fly   259 TISAQAKATVSVLLEPEAHARWNLREILNCAWLR 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	86/272 (32%)
		UBA_AID_AMPKalpha	297..360	CDD:270521
		AMPKA_C	457..580	CDD:213378
CG14305	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	86/271 (32%)
CG14305	NP_650732.1	S_TKc	28..287	CDD:214567	85/265 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940