DRSC/TRiP Functional Genomics Resources

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Protein Alignment AMPKalpha and MARK3

DIOPT Version :10

Sequence 1:NP_477313.1 Gene:AMPKalpha / 43904 FlyBaseID:FBgn0023169 Length:582 Species:Drosophila melanogaster
Sequence 2:NP_001122390.2 Gene:MARK3 / 4140 HGNCID:6897 Length:753 Species:Homo sapiens


Alignment Length:601 Identity:185/601 - (30%)
Similarity:282/601 - (46%) Gaps:131/601 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 AGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQ 78
            |..|:.||  .||:|.|..|:|.|.|.|||:..|.:|..:||:||:::.::.... :.|:.||::
Human    44 ASCADEQP--HIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTS-LQKLFREVR 105

  Fly    79 NLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCH 143
            .:|:..||:|:||::||.|...:::||||.||||:|||:|.||:::|.:||..|:||:|.|.|||
Human   106 IMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 170

  Fly   144 RHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVD 208
            :..|||||||.||||||.:|::||||||.||....|..|.|.||||.|||||:..||.|.|||||
Human   171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVD 235

  Fly   209 IWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEE 273
            :||.|||||.|:.|:||||.:::..|..::..|.:.||.|::....||:.:.|.::|:||..:|:
Human   236 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300

  Fly   274 IKKHEWF-----QKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLA 333
            |.|..|.     :.:|..::.|.....|...||      :....|..:.|:..| ||...:|::.
Human   301 IMKDRWINAGHEEDELKPFVEPELDISDQKRID------IMVGMGYSQEEIQES-LSKMKYDEIT 358

  Fly   334 IAYHLI----------------------------IDN--------------------KRFADDAA 350
            ..|.|:                            ::|                    :|::|.|.
Human   359 ATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAG 423

  Fly   351 NQINEI--------------------------NNFFVAGSPPPPPPPPVPQSSMDHQAPL----A 385
            ..|..:                          :...|.|....|..|.:..:|..::|.:    .
Human   424 PAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKK 488

  Fly   386 TVTVGGGTSASSG-------------TATPVPPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQ 437
            :.||....:||.|             ||.....:..|..:|||     |::..|:.......|..
Human   489 SSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTI-----PDQRTPVASTHSISSAA 548

  Fly   438 TSGGGAFPEKTARGGTPIKRAKWHLGIRSQSKPNDIMLEVYR---AMKALSYEWKIINPYHVRVR 499
            |.....||..||      .|:.:|      .:|.:.....|.   |..:||:|...::.     .
Human   549 TPDRIRFPRGTA------SRSTFH------GQPRERRTATYNGPPASPSLSHEATPLSQ-----T 596

  Fly   500 RQNVKTGKFSKMSLQL 515
            |....|..|||::.:|
Human   597 RSRGSTNLFSKLTSKL 612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AMPKalphaNP_477313.1 STKc_AMPK_alpha 25..280 CDD:270981 123/254 (48%)
UBA_AID_AMPKalpha 297..360 CDD:270521 15/136 (11%)
AMPKA_C 457..580 CDD:213378 14/62 (23%)
MARK3NP_001122390.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
STKc_MARK 55..307 CDD:270974 121/252 (48%)
UBA_MARK3_4 325..367 CDD:270590 11/48 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..600 39/251 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 632..655
MARK1-3_C 654..751 CDD:213381
Blue background indicates that the domain is not in the aligned region.

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