Protein Alignment AMPKalpha and KP78b

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_650065.1
• Gene: KP78b / 41361
• FlyBaseID: FBgn0026063
• Length: 604
• Species: Drosophila melanogaster
• Alignment Length: 518
• Identity: 165/518 - (31%)
• Similarity: 261/518 - (50%)
• Gaps: 61/518 - (11%)

  Fly     6 AAAAEAVAA--GSANGQPLVKIGHYLLG---------ATLGTGTFGKVKIGEHQITRVKVAVKIL 59
            :|||:.|..  ||:.|:...|...|:.|         .|||.|.|.|||:..|..|..:||:|::
  Fly    30 SAAAQNVGGCFGSSGGRSSPKFQSYVNGNGYGVYKIIKTLGKGNFAKVKLAIHLPTGREVAIKLI 94

  Fly    60 NRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQ 124
            ::..:.:: ...|:.||:..:|...||:|::|.|||.:...::::||||||||||:|:||:|:::
  Fly    95 DKTALNTI-ARQKLYREVNIMKKLNHPNIVRLLQVIESERTLYLVMEYVSGGELFNYLVKNGRMR 158

  Fly   125 EHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSP 189
            |..||..|:|::|.::|||...|||||||.||||||..|.:||||||.|........|.|.||||
  Fly   159 ERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLDQQMKLKIADFGFSTTFEPKAPLETFCGSP 223

  Fly   190 NYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVV 254
            .|||||:..||.|:|||||.||.||:||.|:.|:||||..::..|..::..|.:.:|.|::.:..
  Fly   224 PYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPFDGTNLKELRDRVLRGKYRVPYYVSIECE 288

  Fly   255 NLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAYLFPSSIEQDSNV-------IDTYAV--AEVCT 310
            :|:.:.|.::|.:|.::..:....|..         ...||.:.:       :|.:.|  ..:.:
  Fly   289 SLIRKFLVLNPTQRTSLSAVMADRWIN---------MGYEQGNGLRPFQEKPMDLHDVNRLSLLS 344

  Fly   311 KFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQ 375
            ..|.|..:|..| |.....|.:...| :::|..:....|.::        .:||.....|..:|.
  Fly   345 NMGHKPRDVEQS-LKNQKFDDIYCTY-MLLDVAKPRSTACSE--------KSGSSFRETPTAMPG 399

  Fly   376 SSMDHQAPLA--TVTVGGGTSASSGTATPVPPVAGGTPSSTIPIRPH------PERIAPMRDRQL 432
            ||. ...|:|  .||:...|.|.. .:||..|.|    :|..|:.|.      |..:.|...:.:
  Fly   400 SSR-IPVPIAAPNVTISQVTFALD-KSTPNRPAA----TSIRPMAPRLANALTPLPLTPPPKKYI 458

  Fly   433 AMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYH 495
            ..|...:   |.|.::.....| :.|....|:.|   |.|:...:..|.:.|:...|:.:..|
  Fly   459 CCSASKA---ANPRRSEPSSIP-QSAMPKKGVGS---PVDVKTTLLSAQRKLAVNQKLTSASH 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	109/263 (41%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	11/71 (15%)
		AMPKA_C	457..580	CDD:213378	9/39 (23%)
KP78b	NP_650065.1	Protein Kinases, catalytic domain	63..314	CDD:473864	107/251 (43%)
		UBA_MARK_Par1	335..373	CDD:270522	8/39 (21%)