Protein Alignment AMPKalpha and Nuak1

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001369005.1
• Gene: Nuak1 / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Alignment Length: 702
• Identity: 193/702 - (27%)
• Similarity: 289/702 - (41%)
• Gaps: 191/702 - (27%)

  Fly     2 PQMRAAAAEAV------AAGSA----NGQPLVKIGHYLLGAT----------------------- 33
            |...|..|||.      |.|::    :|.|..:|.:.:.|..
  Fly    11 PNGAAGGAEAAAPTGLDATGNSLAHPSGIPQDQIDNIMSGIANTGNVKMNNHRKKLRQRFDIIKK 75

  Fly    34 LGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTP 98
            ||.||:|||::|.::.|..:||:|.:.:.||::...:.:||||:|.:....||:||.:|:|....
  Fly    76 LGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENR 140

  Fly    99 SDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNM 163
            ..:.::||:.:||||:||:.:...|.|.:|||.|:|:.:.|.|||:|.|.|||||.||:|||...
  Fly   141 EKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKG 205

  Fly   164 HVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDD 228
            :.|||||||||:..|...|.|.||||.||:||::.|..|.|||||.||.||:||.|:.|::|||.
  Fly   206 NAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDG 270

  Fly   229 EHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQK----------- 282
            .:...|.::|..|.:..|...:: ...|:..||.|.|.|||:||:|..|.|..:
  Fly   271 SNFKRLVKQISQGDYYEPRKPSR-ASTLIRDMLTVCPRKRASIEQICSHWWVNENDNVSCLDLAE 334

  Fly   283 ----------DLPAYLFPSSIEQDSNVI---DTYAVAEVCTKFGVKETEVHNSLLS-GDPHDQLA 333
                      |:...|.|::|..|..|:   :..|.|:......|..:....|:.. |.|:.:
  Fly   335 DLANQTPVRLDVLLSLTPATITADQLVVPSAEGAAAAKAAANERVPRSHSVGSIRDMGPPNTE-- 397

  Fly   334 IAYHLIIDNKRFADDAA-------------------------------------NQINEINNFFV 361
             |...|:|......:||                                     .:....|:.||
  Fly   398 -AERRILDMVAAGGEAALMPSPTRTITPAQSPVQTKRKLQPTVSTENAAGTTAKKKEKPANSSFV 461

  Fly   362 A---GSPPPPPPPPV--PQSSMDHQAPLATV---------------TVGGGTSASSGTAT---PV 403
            .   |:|....||.:  ||:::.....:|.:               .||.......||||   |.
  Fly   462 ISKDGAPLTEAPPTIIEPQATLMEAETIANIPEEVPVPSYSQKDMQAVGDICDLLMGTATTPAPA 526

  Fly   404 PPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQS 468
            ||..  ||.:..|.|...:.:....:.:.|..|                  ||:      ..::.
  Fly   527 PPAP--TPVARQPTRGKLDAVVETPEEKDATKV------------------IKK------FVNKH 565

  Fly   469 KPNDIMLEVYR-AMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTN 532
            |..|::..:.. |.||.:....:..|..||            |.|||           |..:|..
  Fly   566 KTADLVNAINESASKAAAPVSAVAPPPFVR------------KCSLQ-----------DESTLNK 607

  Fly   533 DEVEQGDDVIMES---LTPPP------------LSVSGVMPLQPTGHHTMEF 569
            ...|:....|:|:   ..|||            ||:.||    ..|....||
  Fly   608 FNAERRKSRILETAEKFQPPPPVAAAPPEKPKKLSIPGV----SVGSFKKEF 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	112/277 (40%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	13/103 (13%)
		AMPKA_C	457..580	CDD:213378	27/129 (21%)
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	110/253 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461608
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840