DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and Brsk1

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_017177814.1	Gene:	Brsk1 / 381979	MGIID:	2685946	Length:	806	Species:	Mus musculus

Alignment Length:	511	Identity:	181/511 - (35%)
Similarity:	268/511 - (52%)	Gaps:	104/511 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHII 89
            :|.|.|..|||.|..|.||:|.|.||..||||||:||:|: |..|:.|:.|||..|||..|||::
Mouse    31 VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAVKIVNREKL-SESVLMKVEREIAILKLIEHPHVL 94

  Fly    90 KLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKP 154
            ||:.|......:::::|:|||||||||:||.|:|...:||:||:||:|.:|:||.:.|.||||||
Mouse    95 KLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKP 159

  Fly   155 ENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYAL 219
            ||||||...:::|||||::::.:....|.||||||:||.||||.|:.|.|...|:|||||||:||
Mouse   160 ENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFAL 224

  Fly   220 LCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWF---- 280
            |.|.|||||:::..|..|:|.|:|.:|.::.....:|:..|::|:|.||.::|:|:||.|:
Mouse   225 LVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGK 289

  Fly   281 -----------QKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAI 334
                       .:.:.....||:.|.|.:|:::.| :..|  |..:| .:|..|.| :..:|..:
Mouse   290 HEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMA-SLGC--FRDRE-RLHRELRS-EEENQEKM 349

  Fly   335 AYHLIIDNK-RF-------------ADDAANQIN-----------------EINNFFVAGSPPPP 368
            .|:|::|.| |:             .|....:::                 |:.:...|||...|
Mouse   350 IYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGSGGSP 414

  Fly   369 PPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPV--------------AGGTPSS---TIP 416
            .|.........|.....:|:......:||..::|..||              .||:|:|   |:|
Mouse   415 VPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLP 479

  Fly   417 IRPHPERIAPMRDRQLAMSVQTSGGGAF---PEKTAR--------------GGTPI 455
            .|      .|            .||||.   |..:||              ||||:
Mouse   480 SR------GP------------RGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	129/254 (51%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	16/93 (17%)
		AMPKA_C	457..580	CDD:213378
Brsk1	XP_017177814.1	STKc_BRSK1_2	32..285	CDD:270983	129/253 (51%)
Brsk1	XP_017177814.1	UBA_BRSK	314..367	CDD:270525	16/57 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910