DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and 4921509C19Rik

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_941057.1	Gene:	4921509C19Rik / 381393	MGIID:	2685851	Length:	640	Species:	Mus musculus

Alignment Length:	591	Identity:	154/591 - (26%)
Similarity:	264/591 - (44%)	Gaps:	98/591 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 HYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKL 91
            ||.:..|||.||||:||:..|.:|:.|||:|||.:.:..||     ::.||:.:|...|||||||
Mouse    23 HYEILTTLGQGTFGEVKLASHLVTQTKVAIKILPKSRKNSL-----VQPEIEIMKSLDHPHIIKL 82

  Fly    92 YQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPEN 156
            ..:|.|..:||:::|:..||||...|.:.|.|.|.:..|.|:|::..:.|||...||||||||||
Mouse    83 LHIIDTTRNIFIVLEHAVGGELMSRIEEFGYLAEVECHRLFKQLVYALQYCHEKGIVHRDLKPEN 147

  Fly   157 LLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLC 221
            :||||..:||:.||||...::.|:.|.|.||:..|.|||:...:.|.|...|:||.||:||.:..
Mouse   148 ILLDHRGNVKLTDFGLGTKIIMGQKLVTFCGTLPYCAPELFEDRGYDGRATDVWSLGVVLYFMAT 212

  Fly   222 GTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPA 286
            |.|||:......:.:||.:|.:|....|:.::..::.::|.|:|.:|..:.:|.:.:|.:.|..|
Mouse   213 GCLPFNGYSYEAIKQKIIAGKYPRSFSLSPELWEVIAKLLTVNPGERPTVHDIARFKWLKPDNEA 277

  Fly   287 YLFPSSIEQDSNVIDTYAVAEVCTKFGV---KETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADD 348
              .|:|:.::   |:::....:....||   ...|:..||.. ...||:...|.::.....:.:.
Mouse   278 --SPASLGEN---IESHPDPSIMVLMGVMGYNPGEIRESLRE-KKFDQVMATYLMLKQQSAWENK 336

  Fly   349 AANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGTPSS 413
            ...:                |.|.:....:....|    |:...||....::.|.        .|
Mouse   337 TTKK----------------PDPRLCDRMLRSTEP----TIKNQTSVRRASSVPT--------HS 373

  Fly   414 TIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTP--------IKRAKWHLGIRSQSKP 470
            |..:....|.:...:...::.|:..: ...|.|:|    ||        :::|.:...|..:::.
Mouse   374 TFSLPNESESLEKGKRTTMSHSMPPT-RNCFNEET----TPLHSICPQLVQKAHYRRSIWGETEI 433

  Fly   471 NDIMLE----------------------------VYRAMKALSYEWKIINPYHVRVRRQNVKTGK 507
            :|...|                            .|...|..|   :.::.:|..|.....:...
Mouse   434 SDTSEESSTGESLEHPSLKIHTLQTSMGVSKAGSTYSKSKGSS---QCVSSHHTSVEEDQCEGTN 495

  Fly   508 FSK-MSLQLYQVDAKSYLLDFKSLTNDEVEQGDDVIMESLTPPPLS---VSGVMPL------QPT 562
            .|: ::..|..|..:..|:....:.......  |::...:|.||.|   ..|..|.      :|:
Mouse   496 ISREINPPLSPVSPQENLMGQLHIVTTAGSM--DIMNTQVTSPPFSRKEAKGEGPALQQRESRPS 558

  Fly   563 GHHTME 568
            ..:|::
Mouse   559 SPNTLQ 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	102/252 (40%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	9/65 (14%)
		AMPKA_C	457..580	CDD:213378	22/150 (15%)
4921509C19Rik	NP_941057.1	STKc_AMPK-like	23..270	CDD:270905	102/251 (41%)
		UBA_MARK_Par1	290..328	CDD:270522	8/38 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..399		7/47 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..509		8/47 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..576		8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	617..640
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010