DRSC/TRiP Functional Genomics Resources

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Protein Alignment AMPKalpha and Melk

DIOPT Version :9

Sequence 1:NP_477313.1 Gene:AMPKalpha / 43904 FlyBaseID:FBgn0023169 Length:582 Species:Drosophila melanogaster
Sequence 2:NP_001382535.1 Gene:Melk / 362510 RGDID:1308974 Length:643 Species:Rattus norvegicus


Alignment Length:381 Identity:143/381 - (37%)
Similarity:206/381 - (54%) Gaps:55/381 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 HYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKL 91
            :|.|..|:|||.|.|||:..|.:|...||:||:::..:.|  .:.:::.||..||..||.||.:|
  Rat    10 YYELYETIGTGGFAKVKLACHILTGEMVAIKIMDKNALGS--DLPRVKTEIDALKNLRHQHICQL 72

  Fly    92 YQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPEN 156
            |.|:.|.:.|||::||..||||||||:...:|.|.:.|..|:||:|.|.|.|.....||||||||
  Rat    73 YHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVIFRQILSAVAYVHSQGYAHRDLKPEN 137

  Fly   157 LLLDHNMHVKIADFGLSNMMLDGE--FLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYAL 219
            ||.|.|..:|:.||||.......:  .|:|.|||..|||||:|.||.|.|.|.|:||.|::||.|
  Rat   138 LLFDENHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVL 202

  Fly   220 LCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDL 284
            :||.|||||::|..|::||..|.:.:|::|:...:.|:.|||||||.:|.:::.:..|.|..:| 
  Rat   203 MCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKRRISMKNLLNHPWILQD- 266

  Fly   285 PAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHN--------SLLSGDPHDQLAIAYHLIID 341
              |..|  ||..|....|: :.|.|    :.|..||:        .|:|...:|.|...|.|::.
  Rat   267 --YSCP--IEWQSKASLTH-LDEDC----ITELSVHHRNSRQTMEDLISSWQYDHLTATYLLLLA 322

  Fly   342 NKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASS 397
            .|                 ..|.|                |.|..::..|||::::
  Rat   323 KK-----------------ARGKP----------------ARLQLLSFSGGTTSTT 345

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AMPKalphaNP_477313.1 STKc_AMPK_alpha 25..280 CDD:270981 116/254 (46%)
UBA_AID_AMPKalpha 297..360 CDD:270521 14/70 (20%)
AMPKA_C 457..580 CDD:213378
MelkNP_001382535.1 STKc_MELK 7..263 CDD:270980 116/254 (46%)
UBA_MELK 281..332 CDD:270526 15/88 (17%)
MELK_C 547..641 CDD:213383
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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