DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and grp

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_477011.1	Gene:	grp / 34993	FlyBaseID:	FBgn0261278	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	410	Identity:	117/410 - (28%)
Similarity:	193/410 - (47%)	Gaps:	74/410 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AAEAVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGK 72
            ||....||:........:..:.|..|||.|.:|:||:..::.|...||:|:::.:  |..|....
  Fly     2 AATLTEAGTGPAATREFVEGWTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLK--KHPDAANS 64

  Fly    73 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIIS 137
            :|:|:...|:.:..||::.:...|..|..::.:||.:||||||.|.....:.:|:|:|:|.|::|
  Fly    65 VRKEVCIQKMLQDKHILRFFGKRSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLS 129

  Fly   138 GVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMM-LDGE--FLRTSCGSPNYAAPEVISG 199
            |::|.|:..|.||||||||||||.:.:|||:|||::.|. ..|:  .|...||:..|.||||:.
  Fly   130 GLNYLHQRGIAHRDLKPENLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVLQ- 193

  Fly   200 KLYAGPEVDIWSCGVILYALLCGTLPF--------------DDEH--VPTLFRKIKSGIFPIPEY 248
            |.|.....|:|||||||..:|.|.||:              |::|  :.|.:.|
  Fly   194 KAYHAQPADLWSCGVILVTMLAGELPWDQPSTNCTEFTNWRDNDHWQLQTPWSK----------- 247

  Fly   249 LNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFG 313
            |:...::|:.::|...|..|..:|:...|:|.....      :..|:..:::|:.|..|:|:...
  Fly   248 LDTLAISLLRKLLATSPGTRLTLEKTLDHKWCNMQF------ADNERSYDLVDSAAALEICSPKA 306

  Fly   314 VKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSM 378
            .::....::.||....|.::..|             .:|                 |.|..:|..
  Fly   307 KRQRLQSSAHLSNGLDDSISRNY-------------CSQ-----------------PMPTMRSDD 341

  Fly   379 DHQAPLATVTVGGGTSASSG 398
            |.     .|.:|.|.|...|
  Fly   342 DF-----NVRLGSGRSKEDG 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	93/273 (34%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	9/62 (15%)
		AMPKA_C	457..580	CDD:213378
grp	NP_477011.1	STKc_Chk1	20..279	CDD:270971	93/272 (34%)
grp	NP_477011.1	S_TKc	22..278	CDD:214567	93/269 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010