DRSC/TRiP Functional Genomics Resources

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Protein Alignment AMPKalpha and HUNK

DIOPT Version :10

Sequence 1:NP_477313.1 Gene:AMPKalpha / 43904 FlyBaseID:FBgn0023169 Length:582 Species:Drosophila melanogaster
Sequence 2:NP_055401.1 Gene:HUNK / 30811 HGNCID:13326 Length:714 Species:Homo sapiens


Alignment Length:638 Identity:176/638 - (27%)
Similarity:300/638 - (47%) Gaps:140/638 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 KIGHYLLGA-TLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGK-IRREIQNLKLFRHP 86
            ::|:||:|: .||.|:|.||:.|.|.:|..|||:|::::::.|....|.| :|||.|..::.|||
Human    57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHP 121

  Fly    87 HIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRD 151
            :|.:|..::.|.:..:::||...||.|...|.:..:|:|.:|||:.:|:||.|::.||..:||||
Human   122 NITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRD 186

  Fly   152 LKPENLLLDHNMHVKIADFGLSN---MMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCG 213
            ||.||||||.:.::|:.||||||   ::...:...|.||||.|||||:::.|.| ||::|:||.|
Human   187 LKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GPKIDVWSIG 250

  Fly   214 VILYALLCGTLPFDDE--HVPTLFRK-IKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIK 275
            |.:||:|.|||||..|  .:..|::| :...:.|:|..|:...::.:..:|:.||:||.||::..
Human   251 VNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQAL 315

  Fly   276 KHEWFQKD----LPAYL-FPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIA 335
            .:.|..::    :|..: :|:.|..:.  :....|..:..|.|.|.::|.|::||......||| 
Human   316 ANRWLNENYTGKVPCNVTYPNRISLED--LSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAI- 377

  Fly   336 YHLI-------IDNKRFADDA---ANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVG 390
            |.|:       :..|....|:   ..::.:|..:            ..|:.|  ::|.|.|.|..
Human   378 YFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKY------------RAPKES--YEASLDTWTRD 428

  Fly   391 GGTSASSGTATPVPPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGG-------------- 441
            ....|............|     ....||..:::    |:.|....|.||.              
Human   429 LEFHAVQDKKPKEQEKRG-----DFLHRPFSKKL----DKNLPSHKQPSGSLMTQIQNTKALLKD 484

  Fly   442 -----GAFPEKTARG---------------------------GTP--IKRAKWH------LGIRS 466
                 .:||:|.:.|                           .||  :|:.:.|      .||..
Human   485 RKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQPGPGSTGIPH 549

  Fly   467 QSKPNDIMLEVYRAMKAL-----------SYEWKIIN-PYHVRVRRQNVKT-------GKFSKMS 512
            :..|  :||::.|:.:::           |:.::|:| |..:..|..:.:|       |..|.:.
Human   550 KEDP--LMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLSPGLPSGSMSPLH 612

  Fly   513 LQLYQVDAKSYLLDF--KSLTNDEVEQGDDVIMESLTPPPLSVSGVMPLQPTG 563
            ..|:..     |:.|  :...:...|:|      ...|||:..:|  |:||.|
Human   613 TPLHPT-----LVSFAHEDKNSPPKEEG------LCCPPPVPSNG--PMQPLG 652

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AMPKalphaNP_477313.1 STKc_AMPK_alpha 25..280 CDD:270981 106/262 (40%)
UBA_AID_AMPKalpha 297..360 CDD:270521 16/72 (22%)
AMPKA_C 457..580 CDD:213378 28/134 (21%)
HUNKNP_055401.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
STKc_HUNK 58..320 CDD:270972 106/262 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 437..471 8/42 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 518..552 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 590..615 4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

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