DRSC/TRiP Functional Genomics Resources

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Protein Alignment AMPKalpha and melk

DIOPT Version :10

Sequence 1:NP_477313.1 Gene:AMPKalpha / 43904 FlyBaseID:FBgn0023169 Length:582 Species:Drosophila melanogaster
Sequence 2:NP_996771.2 Gene:melk / 30724 ZFINID:ZDB-GENE-990603-5 Length:676 Species:Danio rerio


Alignment Length:594 Identity:180/594 - (30%)
Similarity:277/594 - (46%) Gaps:111/594 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 HYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKL 91
            ||.:..|:|:|.|.|||:|.|::|..|||:||:.::.:.  |.:.:::.||:.:|...|.|:.:|
Zfish    12 HYEVYETIGSGGFAKVKLGRHKLTGEKVAIKIMEKKDLG--DDLPRVKIEIEAMKNLSHQHVCRL 74

  Fly    92 YQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPEN 156
            |.||.|.|.|:|::||..||||||||:...:|.|.:.|.||:||||.:.|.|.....||||||||
Zfish    75 YHVIETTSKIYMVLEYCPGGELFDYIIAKDRLSEEETRVFFRQIISALAYVHSQGYAHRDLKPEN 139

  Fly   157 LLLDHNMHVKIADFGLSNMMLDG---EFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYA 218
            ||:|.:.::|:.||||......|   |.| |.||||.|||||:|.||.|.|.|.|:||.||:|||
Zfish   140 LLIDEDHNLKLIDFGLCAKPKGGLGFELL-TCCGSPAYAAPELIQGKAYIGSEADVWSMGVLLYA 203

  Fly   219 LLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKD 283
            ||||.|||||::...|:|||..|.:..|.:|:...:.|:.||:||||.:|..::.:..|.|..:.
Zfish   204 LLCGFLPFDDDNCMVLYRKITRGKYSNPHWLSPSSILLLNQMMQVDPKRRLTVKHLLDHPWAMRG 268

  Fly   284 LPAYLFPSSIEQDSNV----IDTYAVAEVCTKFGVKETEVHN-SLLSGDPHDQLAIAYHLIIDNK 343
                 :.:.:|..|..    ||...:.|:...|  |:::... .|:|...:||:...|.|::..|
Zfish   269 -----YSTPVEWHSKYPLGHIDEDCITEMAVTF--KQSKQRTIQLVSEWKYDQITATYLLLLAKK 326

  Fly   344 RFA---------------------------------DDAANQINEINNFFVAGSPPPPPPPPVPQ 375
            |..                                 ||..:.:       |.||...||      
Zfish   327 RQGRPVRLRAECPVIDIVCSPLQDMQLKKSLRFTEDDDGVHPV-------VLGSMVFPP------ 378

  Fly   376 SSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGTPSST---------------IPIRPHPERIA 425
            ...|.:.|...:|       ...|.|...|.....|.:|               .|.|..|||..
Zfish   379 DCYDDENPWTPLT-------PKNTHTTNTPRMKLYPETTEKWNEMAYSPVIEHSRPCRQKPERRD 436

  Fly   426 PMRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGI-RSQSKPNDIMLEVYRAMKALSYEWK 489
            ..::.:..::|..:.|..|.....|..|..::.|.:..: .:.:..|:...||.:...:.:.|..
Zfish   437 RTKENKENLAVPGTDGDVFALPAPRTPTSSRKVKSNRTVMTTPNHNNNKSSEVNKGAGSATKEGS 501

  Fly   490 IINPYHVRVRRQNV---KTGKFSKMSLQLYQVDAKSYLLDFKSLTND------------EVEQGD 539
                     ||:.|   :.|:..::::..:..:.:|..||......|            .:|:|.
Zfish   502 ---------RRREVEQQQNGQQGELNMLAFSPERRSRSLDLAGCQVDSGQKRKGGKVFGSLERGL 557

  Fly   540 DVIMESLTP 548
            |.::..|||
Zfish   558 DKVITMLTP 566

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AMPKalphaNP_477313.1 STKc_AMPK_alpha 25..280 CDD:270981 120/255 (47%)
UBA_AID_AMPKalpha 297..360 CDD:270521 16/100 (16%)
AMPKA_C 457..580 CDD:213378 19/108 (18%)
melkNP_996771.2 STKc_MELK 9..264 CDD:270980 120/254 (47%)
UBA_MELK 283..334 CDD:270526 13/52 (25%)
UBA-like. /evidence=ECO:0000250 284..323 11/40 (28%)
Autoinhibitory region. /evidence=ECO:0000250 328..673 44/268 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 423..518 19/103 (18%)
MELK_C 577..671 CDD:213383
Blue background indicates that the domain is not in the aligned region.

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