Protein Alignment AMPKalpha and Nuak1

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001100244.1
• Gene: Nuak1 / 299694
• RGDID: 1309956
• Length: 661
• Species: Rattus norvegicus
• Alignment Length: 665
• Identity: 198/665 - (29%)
• Similarity: 290/665 - (43%)
• Gaps: 170/665 - (25%)

  Fly     5 RAAAAEAVAAGSANGQPL-VKIGH--------YLLGATLGTGTFGKVKIGEHQITRVKVAVKILN 60
            |...|.|.||.....:|. ||..|        |.|..|||.||:||||....:.:...||:|.:.
  Rat    24 REVVAGATAAPVEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIR 88

  Fly    61 RQKIK-SLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQ 124
            :.||| .||:| .|||||:.:....|||||.:|:|......|.:||||.|.|||:|||.:..:|.
  Rat    89 KDKIKDELDMV-HIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLS 152

  Fly   125 EHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSP 189
            |.:.|.||:||:|.|.|||::.:||||||.||:|||.|.::|||||||||:....:||:|.||||
  Rat   153 ERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSP 217

  Fly   190 NYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVV 254
            .||:||:::|:.|.|||||.|:.||:||.|:.||:|||......|.|:|.||.:..|.. .....
  Rat   218 LYASPEIVNGRPYRGPEVDSWALGVLLYTLIYGTMPFDGFDHKNLIRQISSGEYREPTQ-PSDAR 281

  Fly   255 NLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAYLFPSSI-------EQDS----NVID-----TY 303
            .|:..||.|:|.:||.||:|..|.|..     :.:.||:       :.:|    .:||     |.
  Rat   282 GLIRWMLMVNPDRRATIEDIANHWWVN-----WGYKSSVCDCDALPDSESPLLARIIDWHHRSTG 341

  Fly   304 AVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPP 368
            ..||...|...|..                 |..::::.:|    :..:..:.|:|..:|....|
  Rat   342 LQAEADAKMKAKPG-----------------ASEVVLERQR----SLKKSKKENDFPQSGQDSLP 385

  Fly   369 PPPPVPQSSMDHQAPLATVTVGGGT---SASSG----------------------TATPVP--PV 406
            ..|    |.:..:.|...:.....:   |.|:|                      ||.|:|  |.
  Rat   386 ESP----SKLSSKRPKGILKKRSNSEHRSHSTGFIEGIVGPALPSPFKMEQDLCRTAIPLPGSPE 446

  Fly   407 AGGT-------PSSTIPIR--------------PHPERIA----------------------PMR 428
            |.|:       .|:|:|.:              ..|||..                      |.|
  Rat   447 AQGSSGKLSLKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNNVIISSGLSSPPPDPAR 511

  Fly   429 DRQLAMSVQTSG------------------GGAFP--EKTARGGTPIKRAKWHLGI-RSQSKPND 472
            ....::|.:..|                  |...|  |..:..|.|..      || ||.|:|:.
  Rat   512 GTSHSLSCRRKGILKHSSRYSDGATDPALTGPEIPTLESLSPPGVPSD------GISRSYSRPSS 570

  Fly   473 IMLEVYRAMKALSYE-WKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDA------KSYLLDFKSL 530
            |:.:    ...||.: :.:::....|..||.:::...::..|||...:.      ..||..:::.
  Rat   571 IISD----DSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQLQDFETPHNRPRPQYLKRYRNR 631

  Fly   531 TNDE----VEQGDDV 541
            ..|.    :...|||
  Rat   632 LADSSFSLLADMDDV 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	124/263 (47%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	11/71 (15%)
		AMPKA_C	457..580	CDD:213378	21/97 (22%)
Nuak1	NP_001100244.1	STKc_NUAK	54..307	CDD:270975	123/254 (48%)
		S_TKc	56..307	CDD:214567	123/252 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910