DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and RGD1560303

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_218667.4	Gene:	RGD1560303 / 292948	RGDID:	1560303	Length:	494	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	131/461 - (28%)
Similarity:	211/461 - (45%)	Gaps:	46/461 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 YLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLY 92
            |.:...||.|...:|::..|::|...||||.|    :|..........|::.:|:..|.:|:.|.
  Rat    29 YTILKPLGQGGTTEVRLSSHRLTGTPVAVKAL----VKHERHWASTMSEVEIMKILNHNNIVSLL 89

  Fly    93 QVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENL 157
            ||:.|..:|::|||...|..|.:.:.|.|:|:|.:||..|.|::|.:.|||...|:||||||:|:
  Rat    90 QVMETEQNIYIIMEVAQGDSLLNRVQKAGRLKEDEARGIFVQLLSALGYCHGKGIIHRDLKPDNI 154

  Fly   158 LLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCG 222
            ::|.:.:|||.||||....|.|:.|:..||:..:..||:..|..|.||:||||:.||:||.::.|
  Rat   155 IVDEHGNVKIIDFGLGAKFLPGQKLKRLCGAFQFIPPELFLGLPYDGPKVDIWALGVLLYFMVTG 219

  Fly   223 TLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAY 287
            ..||....:..|.:.:..|.:.||..|:|.:.:::..:|.|:..:|...:::..|.|.|:.....
  Rat   220 FAPFSGTTLSELSKNVLQGRYDIPYNLSKDLRSMISLLLTVNARQRPTAQDLSSHPWLQEWGKTL 284

  Fly   288 LFPSSIEQDSNVIDTYAVAEVCTKFG-----VKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFAD 347
            .|.|:.:......|.....|   ..|     :||:..|...      |:....|.|:  ..:...
  Rat   285 TFHSNRDTSFPNRDIMVAME---NIGFHVQDIKESLKHKKF------DETMATYLLL--RVQACQ 338

  Fly   348 DAANQINE------INNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTS----ASSGTATP 402
            :..|.:..      :..|..|..|...|.||..::|    .|...:.|.....    .|.||..|
  Rat   339 NGGNYVQTKLLNPGVAPFPSAADPDTFPLPPRRRAS----EPSLKIVVASSEQQRLRQSGGTNAP 399

  Fly   403 VPPVAGGTPSSTIPIRPHPERIAP--MRDRQLAMSVQTSGGGAFPE-----KTARGGTPIKRAKW 460
            |.|..  ||   :..|.:...:..  :..|...|:|.|....|..:     :.:|...|...|||
  Rat   400 VQPKK--TP---VMGRGYKRCVTDPCILRRNTGMNVDTISFSASSQTLSDSERSRSLQPRGWAKW 459

  Fly   461 HLGIRS 466
            ...||:
  Rat   460 KKRIRA 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	87/251 (35%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	10/73 (14%)
		AMPKA_C	457..580	CDD:213378	5/10 (50%)
RGD1560303	XP_218667.4	STKc_AMPK-like	28..276	CDD:270905	87/250 (35%)
		S_TKc	29..277	CDD:214567	87/251 (35%)
		UBA_MARK_Par1	295..332	CDD:270522	8/45 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010