Protein Alignment AMPKalpha and Hunk

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001178591.1
• Gene: Hunk / 288275
• RGDID: 1565091
• Length: 714
• Species: Rattus norvegicus
• Alignment Length: 636
• Identity: 177/636 - (27%)
• Similarity: 301/636 - (47%)
• Gaps: 136/636 - (21%)

  Fly    24 KIGHYLLGA-TLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGK-IRREIQNLKLFRHP 86
            ::|:||:|: .||.|:|.||:.|.|.:|..|||:|::::::.|....|.| :|||.|..::.|||
  Rat    57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHP 121

  Fly    87 HIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRD 151
            :|.:|..::.|.:..:::||...||.|...|.:..:|.|.:|||:.:|:||.|::.||..:||||
  Rat   122 NITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLDEAEARRYIRQLISAVEHLHRAGVVHRD 186

  Fly   152 LKPENLLLDHNMHVKIADFGLSN---MMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCG 213
            ||.||||||.:.::|:.||||||   ::...:...|.||||.|||||:::.|.| ||::|:||.|
  Rat   187 LKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GPKIDVWSIG 250

  Fly   214 VILYALLCGTLPFDDE--HVPTLFRK-IKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIK 275
            |.:||:|.|||||..|  .:..|::| :...:.|:|..|:...:|.:..:|:.||:||.||::..
  Rat   251 VNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAINFLRSLLEPDPVKRPNIQQAL 315

  Fly   276 KHEWFQKD----LPAYL-FPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIA 335
            .:.|..::    :|..: :|:.|..:.  :....|..:..|.|.|.::|.|::||......|||
  Rat   316 ANRWLNENYTGKVPCNVTYPNRISLED--LSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAI- 377

  Fly   336 YHLI-------IDNKRFADDA---ANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVG 390
            |.|:       :..|....|:   ..|:.:|........|              ::|.|.|.|..
  Rat   378 YFLLNKKLERYLSGKSDIQDSICYKTQLYQIEKCRATKEP--------------YEASLDTWTKD 428

  Fly   391 GGTSASSGTATPVPPVAGGTP------------------SSTIPI--RPHPERIAPMRDRQLAMS 435
            ....|          |....|                  ..::|.  :|.|..|..:::.:..:.
  Rat   429 FELHA----------VQDKKPKEQDKRADFLHRPFSKKLDKSLPSHKQPSPSLITQIQNTKALLK 483

  Fly   436 VQTSGGGAFPEKTARG---------------------------GTP--IKRAKWHL-GIRSQS-- 468
            .:.:....|.:|.:.|                           .||  :|:.:.|. |..|.|
  Rat   484 DRKASKSGFGDKDSFGCRNLFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKQEPHQPGPGSASML 548

  Fly   469 -KPNDIMLEVYRAMKAL-----------SYEWKII-NPYHVRVRRQNVKT---GKFSKMSLQLYQ 517
             |...::|::.|:.:::           |:.::|: :|..:..|....:|   |..|..:..| |
  Rat   549 PKEEPLLLDMVRSFESVDREDHIELLSSSHHYRILSSPVSLARRNSGERTLSPGLLSGSTSPL-Q 612

  Fly   518 VDAKSYLLDFKSLTNDE-----VEQGDDVIMESLTPPPLSVSGVMPLQPTG 563
            ....|.|:.|   |::|     .|:|      ..:|||:..:|:|  ||.|
  Rat   613 TPLHSTLVSF---THEEKNSPPKEEG------VCSPPPVPSNGLM--QPLG 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	107/262 (41%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	17/72 (24%)
		AMPKA_C	457..580	CDD:213378	31/131 (24%)
Hunk	NP_001178591.1	STKc_HUNK	58..320	CDD:270972	107/262 (41%)